{"id":3161,"date":"2021-12-08T14:11:00","date_gmt":"2021-12-08T14:11:00","guid":{"rendered":"https:\/\/fusfoundation.org\/?post_type=sw_disease_condition&#038;p=3161"},"modified":"2025-06-05T11:33:11","modified_gmt":"2025-06-05T15:33:11","slug":"retinal-injury","status":"publish","type":"sw_disease_condition","link":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/retinal-injury\/","title":{"rendered":"Retinal Injury"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-focused-ultrasound-therapy\">Focused Ultrasound Therapy<\/h2>\n\n\n\n<p>Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with retinal injury. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the brain without damaging surrounding normal tissue.<\/p>\n\n\n\n<p><strong>How it Works<\/strong><br>Where the beams converge, focused ultrasound produces several therapeutic effects that are being evaluated. One mechanism is to temporarily open the blood-brain barrier, which can be used to allow genetic material or therapeutic agents to enter the region. A second mechanism is using focused ultrasound for neuromodulation of the retinal ganglion cells. While significant preclinical work has been accomplished, there is still much to be done before this technology will be widely available.<br><br><strong>Advantages<\/strong><br>The primary options for treatment of retinal injury are primarily surgical.<br><br>For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications \u2013 such as surgical wound healing or infection \u2013 at a lower cost. It can reach the desired target without damaging surrounding tissue and is repeatable, if necessary.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials\">Clinical Trials<\/h2>\n\n\n\n<p>At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of retinal injury.<\/p>\n\n\n\n<p>The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click <a href=https://www.fusfoundation.org/"https:////clinicaltrials.gov//search?cond=Retinal%20Disease&amp;term=focused%20ultrasound&amp;aggFilters=status:not%20rec\%22 target=\"_blank\" rel=\"noreferrer noopener\"><strong>here<\/strong>,<\/a> it will take you to the latest information available from <a href=https://www.fusfoundation.org/"https:////www.clinicaltrials.gov///" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/www.clinicaltrials.gov\/<\/strong><\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-regulatory-approval-and-reimbursement-nbsp\">Regulatory Approval and Reimbursement&nbsp;<\/h2>\n\n\n\n<p>Focused ultrasound treatment for retinal injury is not yet approved by regulatory bodies or covered by medical insurance companies.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-notable-papers\">Notable Papers<\/h2>\n\n\n\n<p>Park Y, Shin J, Park J, Kim S, Park JH, Kim J, Kim CS, Chang JW, Schuurmans C, Aubert I, Chang WS, Eom K. <a class=\"ek-link\" href=https://www.fusfoundation.org/"https:////pubmed.ncbi.nlm.nih.gov//38713474///" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Focused Ultrasound as a Novel Non-Invasive Method for the Delivery of Gold Nanoparticles to Retinal Ganglion Cells<\/strong><\/a>. Transl Vis Sci Technol. 2024 May 1;13(5):5. doi: 10.1167\/tvst.13.5.5. PMID: 38713474&nbsp;<\/p>\n\n\n\n<p>Bourdin A, Ortoli M, Karadayi R, Przegralek L, Sennlaub F, Bodaghi B, Guillonneau X, Carpentier A, Touhami S. <a href=https://www.fusfoundation.org/"https:////pubmed.ncbi.nlm.nih.gov//37514082///" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Efficacy\u202fand\u202fSafety\u202fof\u202fLow-Intensity\u202fPulsed\u202fUltrasound-Induced Blood-Retinal Barrier Opening in Mice<\/strong><\/a>. Pharmaceutics. 2023 Jul 6;15(7):1896. doi: 10.3390\/pharmaceutics15071896. PMID:\u202f37514082\u202f&nbsp;<\/p>\n\n\n\n<p>Xu C, Lu G, Kang H, Humayun MS, Zhou Q. <strong><a aria-label=\" (opens in a new tab)\" href=https://www.fusfoundation.org/"https:////pubmed.ncbi.nlm.nih.gov//36144157///" target=\"_blank\" rel=\"noreferrer noopener\" class=\"ek-link\">Design and Simulation of a Ring Transducer Array for Ultrasound Retinal Stimulation<\/a><\/strong>. Micromachines (Basel). 2022 Sep 16;13(9):1536. doi: 10.3390\/mi13091536. <\/p>\n\n\n\n<p>Lu G, Qian X, Castillo J, Li R, Jiang L, Lu H, Kirk Shung K, Humayun MS, Thomas BB, Zhou Q.&nbsp;<a href=https://www.fusfoundation.org/"https:////pubmed.ncbi.nlm.nih.gov//32746196///" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Transcranial Focused Ultrasound for Noninvasive Neuromodulation of the Visual Cortex<\/strong><\/a>. IEEE Trans Ultrason Ferroelectr Freq Control. 2021 Jan;68(1):21-28. doi: 10.1109\/TUFFC.2020.3005670. Epub 2020 Dec 23.<\/p>\n\n\n\n<p>Touahri Y, Dixit R, Kofoed RH, Miloska K, Park E, Raeisossadati R, Markham-Coultes K, David LA, Rijal H, Zhao J, Lynch M, Hynynen K, Aubert I, Schuurmans C.\u00a0<strong><a href=https://www.fusfoundation.org/"https:////www.ncbi.nlm.nih.gov//pubmed//32194850/" target=\"_blank\" rel=\"noreferrer noopener\">Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal M\u00fcller glia<\/a><\/strong>. Theranostics. 2020 Feb 10;10(7):2982-2999. doi: 10.7150\/thno.42611. eCollection 2020.<\/p>\n\n\n\n<p><strong><a href=https://www.fusfoundation.org/"https:////www.ncbi.nlm.nih.gov//pubmed//?term=(%22focused+ultrasound%22+OR+HIFU)+and+%22retinal%22\%22 target=\"_blank\" rel=\"noreferrer noopener\"><strong>Click <\/strong>here<\/a> for additional references from PubMed.<\/strong><\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":false,"_editorskit_reading_time":2,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"sw_disease_condition_cat":[27],"sw_disease_condition_stage":[14],"class_list":["post-3161","sw_disease_condition","type-sw_disease_condition","status-publish","hentry","sw_disease_condition_cat-ophthalmological"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Retinal Injury - Focused Ultrasound Foundation<\/title>\n<!-- Added by HTTrack --><meta http-equiv="content-type" content="text/html;charset=utf-8" /><!-- /Added by HTTrack -->
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