Miscellaneous Archives - Focused Ultrasound Foundation https://www.fusfoundation.org/diseases-and-conditions/miscellaneous/ Thu, 14 May 2026 19:03:48 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.4 https://cdn.fusfoundation.org/2022/04/04161400/cropped-favicon-32x32.png Miscellaneous Archives - Focused Ultrasound Foundation https://www.fusfoundation.org/diseases-and-conditions/miscellaneous/ 32 32 Solar Lentigo https://www.fusfoundation.org/diseases-and-conditions/solar-lentigo/ Thu, 14 May 2026 18:04:19 +0000 https://www.fusfoundation.org/?post_type=sw_disease_condition&p=40912 Focused Ultrasound Therapy 

Focused ultrasound is a therapeutic technology that could transform the quality of life and decrease the cost of care for patients with solar lentigo. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue. 

How it Works 
Where the beams converge, focused ultrasound produces several therapeutic effects that are being evaluated. The energy from high intensity focused ultrasound impacts the targeted tissue and causes tightening of the tissue and an alteration of the underlying tissue mechanics that results in an increased tension of supporting structures as well.  

The primary options for treatment of solar lentigo include laser therapy, cryotherapy, and chemical peels. For certain patients, focused ultrasound could provide a noninvasive alternative with possible increased efficacy to existing medical therapy.  

Advantages 

  • Focused ultrasound is noninvasive, so it does not carry added concerns like surgical wound healing or infection.  
  • Focused ultrasound can reach the desired target without damaging surrounding tissue. 
  • It can be repeated, if necessary. 

Clinical Trials 

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of solar lentigo.  

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here, it will take you to the latest information available from https://www.clinicaltrials.gov/.  

Regulatory Approval and Reimbursement  

Focused ultrasound treatment for solar lentigo is not yet approved by regulatory bodies or covered by medical insurance companies. 

Notable Papers 

Pan R, Gu D, Ye Q, Meng X, Liu T, Lu Y, Xu Y. Safety and efficacy of high-intensity macro-focused ultrasound for solar lentigo in Chinese patients: a prospective study. J Dermatolog Treat. 2025 Dec;36(1):2562312. doi: 10.1080/09546634.2025.2562312. Epub 2025 Sep 19. PMID: 40970596. 

Click here for additional references from PubMed.   

]]> Twin Twin Transfusion Syndrome  https://www.fusfoundation.org/diseases-and-conditions/twin-twin-transfusion-syndrome/ Thu, 04 Sep 2025 20:54:54 +0000 https://www.fusfoundation.org/?post_type=sw_disease_condition&p=36791 Focused Ultrasound Therapy 

Focused ultrasound is a rapidly evolving, therapeutic technology that could transform the quality of life and decrease the cost of care for patients with twin twin transfusion syndrome. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue. 

How it Works 

Where the beams converge, focused ultrasound produces a therapeutic vascular occlusion of the larger placental vessels to one of the twins to try to balance the perfusion between the two twins. This treatment has been accomplished in a small number of patients, and publication of the results is expected soon. 

The primary options for treatment of twin twin transfusion syndrome are very limited, and if left untreated, can result in damage to both of the twins. Some situations offer a decision to sacrifice one of the twins to enable the other one to survive.  

For certain patients, a non-invasive alternative is a welcome option for patients that have twin twin transfusion syndrome.  

Advantages 

  • Focused ultrasound is non-invasive, so it does not carry added concerns like surgical wound healing or infection.  
  • Focused ultrasound can reach the desired target without damaging surrounding tissue. 
  • It can be repeated, if necessary. 

Clinical Trials 

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of twin twin transfusion syndrome.  

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here, it will take you to the latest information available from https://www.clinicaltrials.gov/.  

Regulatory Approval and Reimbursement  

Focused ultrasound treatment for twin twin transfusion syndrome is not yet approved by regulatory bodies or covered by medical insurance companies.  

See here for a list of clinical trials sites 

Notable Papers 

Carlucci S, Lees C, Miloro P, Papastefanou I, Ter Haar G, Dall’Asta A. Doppler ultrasound and first trimester pregnancy: not always a happy marriage. Hum Reprod. 2024 Aug 24:deae176. doi: 10.1093/humrep/deae176. Epub ahead of print. PMID:39180766. 

Expert Rev Hematol. 2020 Mar;13(3):259-267. Twin-twin transfusion syndrome in the era of fetoscopic laser surgery: antenatal management, neonatal outcome and beyond. doi: 10.1080/17474086.2020.1720643. Epub 2020 Jan 31. PMID: 31971028

Janwadkar R, Leblang S, Ghanouni P, Brenner J, Ragheb J, Hennekens CH, Kim A, Sharma K. Focused Ultrasound for Pediatric Diseases. Pediatrics. 2022 Mar 1;149(3):e2021052714. doi: 10.1542/peds.2021-052714. PMID: 35229123 

Salvesen K, Abramowicz J, Ter Haar G, Miloro P, Sinkovskaya E, Dall’Asta A, Maršál K, Lees C Board of the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG). ISUOG statement on the safe use of Doppler for fetal ultrasound examination in the first 13 + 6 weeks of pregnancy (updated). Ultrasound Obstet Gynecol. 2021 Jun;57(6):1020. doi: 10.1002/uog.23610. PMID: 34077607. 

Smith SF, Miloro P, Axell R, Ter Haar G, Lees C. In vitro characterisation of ultrasound-induced heating effects in the mother and fetus: A clinical perspective. Ultrasound. 2021 May;29(2):73-82. doi: 10.1177/1742271X20953197. Epub 2020 Sep 14. PMID:33995553; PMCID: PMC8083135. 

Spruijt MS, Lopriore E, J Steggerda S, Slaghekke F, Van Klink JMM. Twin-twin transfusion syndrome in the era of fetoscopic laser surgery: antenatal management, neonatal outcome and beyond. 

Shaw CJ, Rivens I, Civale J, Botting KJ, Allison BJ, Brain KL, Niu Y, Ter Haar G, Giussani DA, Lees CC. Maternal and fetal cardiometabolic recovery following ultrasound-guided high-intensity focused ultrasound placental vascular occlusion. J R Soc Interface. 2019 May 31;16(154):20190013. doi: 10.1098/rsif.2019.0013. PMID: 31039691 

Shaw CJ, Civale J, Botting KJ, Niu Y, Ter Haar G, Rivens I, Giussani DA, Lees CC. Noninvasive high-intensity focused ultrasound treatment of twin-twin transfusion syndrome: A preliminary in vivo study. Sci Transl Med. 2016 Jul 13;8(347):347ra95. doi: 10.1126/scitranslmed.aaf2135. PMID: 27412787  

Click here for additional references from PubMed.   

]]> Burns https://www.fusfoundation.org/diseases-and-conditions/burns/ Fri, 15 Aug 2025 19:42:22 +0000 https://www.fusfoundation.org/?post_type=sw_disease_condition&p=36447 Focused Ultrasound Therapy 

Focused ultrasound is a rapidly evolving, therapeutic technology that could transform the quality of life and decrease the cost of care for patients with burns. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue. 

How it Works 

Where the beams converge, focused ultrasound produces Low Intensity Pulsed Ultrasound aimed at the spleen that has shown to help reduce inflammation and improve healing for patients with sustained burns.   

The primary options for treatment of burns include medication and invasive surgery, and the challenge of inflammation and wound healing can be an ongoing challenge.  

For certain patients, focused ultrasound could provide a supplement to the medications and surgery.  

Advantages 

  • Focused ultrasound is non-invasive, so it does not carry added concerns like surgical wound healing or infection.  
  • Focused ultrasound can reach the desired target without damaging surrounding tissue. 
  • It can be repeated, if necessary. 

Clinical Trials 

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of burns.  

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here, it will take you to the latest information available from https://www.clinicaltrials.gov/.  

Regulatory Approval and Reimbursement  

Focused ultrasound treatment for burns is not yet approved by regulatory bodies or covered by medical insurance companies. 

Notable Papers 

Raihane AS, Armstrong DG, Gillenwater TJ, Galiano RD. Advancing Therapeutic Solutions for Burn Wounds: Potential Use of Noninvasive Ultrasound-Driven Splenic Stimulation. Adv Wound Care (New Rochelle). 2025 Mar 27. doi: 10.1089/wound.2024.0181. Online ahead of print. PMID: 40147451 

Click here for additional references from PubMed.

]]> Equine Sarcoid https://www.fusfoundation.org/diseases-and-conditions/equine-sarcoid/ Wed, 13 Nov 2024 20:24:00 +0000 https://fusfoundation-redesign.storywaredev.com/?post_type=sw_disease_condition&p=29711 Focused Ultrasound Therapy 

Focused ultrasound is a rapidly evolving, therapeutic technology that could transform the quality of life and decrease the cost of care for horses that have developed equine sarcoid. These predominantly benign, lesions can take a variety of forms, ranging from scaling and crusting with variable alopecia to (less frequently) lumps or tumor like masses. They can be disabling for horses, as they can frequently involve the eyes, ears and girth regions. Bovine papillomavirus is important in its etiology. This novel technology focuses beams of ultrasound energy precisely and accurately on targets in the body without damaging surrounding normal tissue. 

How it Works 

Focused ultrasound will use the mechanical effect of histotripsy to disrupt the physical structure of the targeted equine sarcoid. This effort will be done in several different doses, and there will be immunotherapeutic biomarkers captured that will be contrasted with non-histotripsy level.  

The primary options for treatment of equine sarcoid includes medication and possibly chemotherapy, but the recurrent nature of these lesions makes this an unmet need for horse owners.  

For certain patients, focused ultrasound could provide a more effective alternative to the limited conventional options that currently exist. While significant work has been accomplished, there is still much to be done before this technology will be widely available. 

Advantages 

  • Focused ultrasound is non-invasive, so it does not carry added concerns like surgical wound healing or infection.  
  • Focused ultrasound can reach the desired target without damaging surrounding tissue. 
  • It can be repeated, if necessary. 

Clinical Trials 

This therapy is currently only seen in horses. There is an active clinical trial operating at Virginia Tech.   

Regulatory Approval and Reimbursement  

Focused ultrasound treatment for equine sarcoid is not yet approved by regulatory bodies or covered by medical (horse) insurance companies. 

Notable Papers 

Ellero N, Maggi A, Busoni V, Imposimato I, Castagnetti C, Lanci A, Mariella J, Freccero F. Development and application of a focused ultrasound protocol in neonatal foals. Vet J. 2026 Feb;315:106543. doi: 10.1016/j.tvjl.2025.106543. Epub 2025 Dec 27. PMID: 41461358 

Haspeslagh M, Vlaminck LE, Martens AM. Treatment of sarcoids in equids: 230 cases (2008-2013). J Am Vet Med Assoc. 2016 Aug 1;249(3):311-8. doi: 10.2460/javma.249.3.311. PMID: 27439349  

Staiger EA, Tseng CT, Miller D, Cassano JM, Nasir L, Garrick D, Brooks SA, Antczak DF. Host genetic influence on papillomavirus-induced tumors in the horse. Int J Cancer. 2016 Aug 15;139(4):784-92. doi: 10.1002/ijc.30120. Epub 2016 May 6. PMID: 27037728 

Click here for additional references from PubMed.   

]]> Niemann-Pick Disease https://www.fusfoundation.org/diseases-and-conditions/niemann-pick-disease/ Fri, 28 Jan 2022 14:25:00 +0000 https://fusfoundation.org/?post_type=sw_disease_condition&p=3270 Focused Ultrasound Therapy

Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with Niemann-Pick Disease. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue.

How it Works
Patients with Niemann-Pick disease lack certain enzymes for the metabolism of fat. Where the focused ultrasound beams converge, transient opening of the blood-brain barrier (BBB) can allow enhanced penetration into the central nervous system of a synthetic replacement enzyme.

Another area being explored is using focused ultrasound for transient BBB opening to allow modified RNA penetration into the central nervous system, enabling production of the needed enzyme. Preclinical research for both of these mechanisms is being evaluated.

Advantages
The primary options for treatment of Niemann-Pick Disease are primarily supportive therapies as there is no cure.

For certain patients, focused ultrasound could provide a therapeutic option for these patients. While significant work has been accomplished, there is still much to be done before this technology will be widely available.

Focused ultrasound is noninvasive, so it does not carry added concerns like surgical wound healing or infection. It can also reach the desired target without damaging surrounding tissue and is repeatable, if necessary.

Clinical Trials

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of Niemann-Pick disease.

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here, it will take you to the latest information available from https://www.clinicaltrials.gov/. 

Regulatory Approval and Reimbursement 

Focused ultrasound treatment for Niemann-Pick disease is not yet approved by regulatory bodies or covered by medical insurance companies.

Notable Papers

Carradori D, Chen H, Werner B, Shah AS, Leonardi C, Usuelli M, Mezzenga R, Platt F, Leroux JC. Investigating the Mechanism of Cyclodextrins in the Treatment of Niemann-Pick Disease Type C Using Crosslinked 2-Hydroxypropyl-beta-cyclodextrin. Small. 2020 Nov;16(46):e2004735. doi: 10.1002/smll.202004735. Epub 2020 Oct 20. PMID: 33079457

Click here for additional references from PubMed.

]]> Hypersplenism https://www.fusfoundation.org/diseases-and-conditions/hypersplenism/ Wed, 08 Dec 2021 14:23:00 +0000 https://fusfoundation.org/?post_type=sw_disease_condition&p=3258 Focused Ultrasound Therapy

Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with hypersplenism. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue.

How it Works
Where the beams converge, focused ultrasound produces precise ablation (thermal destruction of tissue) enabling hypersplenism to be treated without surgery. Initial reports have shown that treatment can result in improvements in pancytopenia and also reduction in gingival bleeding and epistaxis.

Advantages
The primary options for treatment of hypersplenism include medications or surgery.

For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications – such as infection, blood loss, or scarring – at a lower cost. It also involves a shorter recovery time and can be repeatable, if necessary.

Clinical Trials

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of hypersplenism.

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here, it will take you to the latest information available from https://www.clinicaltrials.gov/.

Find a Treatment Site

Search for a treatment center or clinical trial near you.

Regulatory Approval and Reimbursement

Focused ultrasound treatment for hypersplenism is not yet approved by regulatory bodies or covered by medical insurance companies.

Notable Papers

Zhang X, Tang S, Huang G, Xu Z, Feng C, Yan G, He S. Minimally invasive treatment of cirrhotic secondary hypersplenism with high-intensity focused ultrasound. Sci Rep. 2022 Nov 30;12(1):20700. doi: 10.1038/s41598-022-24416-x.

Zhu J, Chen X, Hu X, Zhu H, He C. A Comparative Study of Surgical Splenectomy, Partial Splenic Embolization, and High-Intensity Focused Ultrasound for Hypersplenism. J Ultrasound Med. 2016 Mar;35(3):467-74. doi: 10.7863/ultra.15.03050. Epub 2016

Zhu J, Zhu H, Mei Z, Zhang L, Jin C, Ran L, Zhou K, Yang W. High-intensity focused ultrasound ablation: an effective and safe treatment for secondary hypersplenism. Br J Radiol. 2014 Nov;87(1043):20140374. doi: 10.1259/bjr.20140374. Epub 2014 Aug 20.

Zhu J, Zhu H, Mei Z, Jin C, Ran L, Zhou K, Yang W, Zhang L, She C. High-intensity focused ultrasound ablation for treatment of hepatocellular carcinoma and hypersplenism: preliminary study. J Ultrasound Med. 2013 Oct;32(10):1855-62. doi: 10.7863/ultra.32.10.1855.

Click here for additional references from PubMed.

]]> Infection  https://www.fusfoundation.org/diseases-and-conditions/infection/ Wed, 08 Dec 2021 14:23:00 +0000 https://fusfoundation.org/?post_type=sw_disease_condition&p=3261 Focused Ultrasound Therapy

Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients who are infected or who are at risk for infection because of foreign bodies (FB) that are present in their body. Infectious agents can infect FB or can produce biofilms that coat the surface of the FB and allow adherence of the infection to the biofilm, either of which can cause serious adverse impact to the patient. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue.

How it Works
Where the beams converge, the ultrasound produces precise ablation (thermal destruction of the target) potentially enabling biofilms and/or infection to be treated without surgery. Another option is to use focused ultrasound’s ability to temporarily open the blood-brain barrier (BBB) and allow therapeutic agents to treat infectious agents in the brain. Work is planned to insert CRISPR/Cas-9 aimed at targeting intracranial HIV. While significant work has been accomplished, there is still much to be done before this technology will be widely available.

Advantages
The primary options for treatment of infection of FBs include medication or surgery to remove the FB.

For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications – including surgical wound healing – at a lower cost.  It can also reach the desired target without damaging surrounding tissue and is repeatable, if necessary.

Clinical Trials

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of infection or biofilms.

Regulatory Approval and Reimbursement 

Focused ultrasound treatment for infection or biofilms is not yet approved by regulatory bodies or covered by medical insurance companies.

Notable Papers

Liu ZH, Chen NY, Huang CY, Lin YJ, Yip PK, Wei KC, Liu HL. Modulation of the immune response by focused ultrasound suppressed brain abscess formation. Drug Deliv Transl Res. 2026 Mar;16(3):1007-1019. doi: 10.1007/s13346-025-01847-3. Epub 2025 Apr 7. PMID: 40193008 

Fritz K, Salavastru C, Eren S, Tiplica GS. Botulinumtoxin A in simultaneous combination with lasers and energy-based devices (EBD). [Original Title: Botulinumtoxin A in zeitgleicher Kombination mit Lasern und EBD („energy-based devices“).] Dermatologie (Heidelb). 2026 Jan 16. doi: 10.1007/s00105-025-05637-3. PMID: 41543534 

Li CH, Chao WH, Wu PC, Fan CH. Remote biofilm dislodgment using focused acoustic vortex. Ultrason Sonochem. 2025 Oct;121:107423. doi: 10.1016/j.ultsonch.2025.107423. Epub 2025 Jun 14. PMID: 40537365 

Bigelow TA, Petersen AC, Chikhwaza DA, Wu H, Yu H, Gupta K, Itani KMF. Impact of low-amplitude pulse interspersed with histotripsy treatment of Staphylococcus aureus biofilms on Surgical Mesh. Ultrasonics. 2025 Jul 5;156:107730. doi: 10.1016/j.ultras.2025.107730. PMID: 40633167 

Liu M, Zhang X, Xiao L, Liang J, Cheng D, Zhu Y, Chang S. The comparison of fractional CO2 laser and focused ultrasound for vulvar lichen sclerosus: a retrospective study. Int J Hyperthermia. 2025 Dec;42(1):2507958. doi: 10.1080/02656736.2025.2507958. Epub 2025 May 25. PMID: 40415409 

Ambekar PA, Wang YN, Khokhlova T, Bruce M, Leotta DF, Totten S, Maxwell AD, Chan K, Liles WC, Dellinger EP, Monsky W, Adedipe AA, Matula TJ. Comparative Study of Histotripsy Pulse Parameters Used to Inactivate Escherichia coli in Suspension. Ultrasound Med Biol. 2023 Sep 15:S0301-5629(23)00251-X. doi: 10.1016/j.ultrasmedbio.2023.08.004. PMID: 37718123 

Morse R, Childers C, Nowak E, Rao J, Vlaisavljevich E. Catheter-Based Medical Device Biofilm Ablation Using Histotripsy: A Parameter Study. Ultrasound Med Biol. 2023 Jul 1:S0301-5629(23)00203-X. doi: 10.1016/j.ultrasmedbio.2023.06.010. PMID: 37394375 

Ouyang M, Ouyang X, Peng Z, Liu M, Xu G, Zou Z, Zhang M, Shang Q. Heart-targeted amelioration of sepsis-induced myocardial dysfunction by microenvironment responsive nitric oxide nanogenerators in situ. J Nanobiotechnology. 2022 Jun 7;20(1):263. doi: 10.1186/s12951-022-01457-y.

Wang G, Wu W, Zhu JJ, Peng D. The promise of low-intensity ultrasound: A review on sonosensitizers and sonocatalysts by ultrasonic activation for bacterial killing. Ultrason Sonochem. 2021 Nov;79:105781. doi: 10.1016/j.ultsonch.2021.105781. Epub 2021 Oct 9.

Matula TJ, Wang YN, Khokhlova T, Leotta DF, Kucewicz J, Brayman AA, Bruce M, Maxwell AD, MacConaghy BE, Thomas G, Chernikov VP, Buravkov SV, Khokhlova VA, Richmond K, Chan K, Monsky W. Treating Porcine Abscesses with Histotripsy: A Pilot Study. Ultrasound Med Biol. 2021 Mar;47(3):603-619. doi: 10.1016/j.ultrasmedbio.2020.10.011. Epub 2020 Nov 26.

Hu Y, Mo Y, Wei J, Yang M, Zhang X, Chen X. Programmable and monitorable intradermal vaccine delivery using ultrasound perforation array. Int J Pharm. 2022 Feb 18;617:121595. doi: 10.1016/j.ijpharm.2022.121595.

Childers C, Edsall C, Gannon J, Whittington A, Muelenaer A, Rao J, Vlaisavljevich E. Focused Ultrasound Biofilm Ablation: Investigation of Histotripsy for the Treatment of Catheter-Associated Urinary Tract Infections (CAUTIs). IEEE Trans Ultrason Ferroelectr Freq Control. 2021 May 5;PP. doi: 10.1109/TUFFC.2021.3077704.

Bharatula LD, Marsili E, Rice SA, Kwan JJ. Influence of High Intensity Focused Ultrasound on the Microstructure and c-di-GMP Signaling of Pseudomonas aeruginosa Biofilms. Front Microbiol. 2020 Dec 15;11:599407. doi: 10.3389/fmicb.2020.599407. eCollection 2020.

Apostolakis S. Use of Focused Ultrasound (Sonication) for the Diagnosis of Infections in Neurosurgical Operations: A Systematic Review and Meta-Analysis. World Neurosurg. 2020 Apr;136:364-373.e2. doi: 10.1016/j.wneu.2019.12.143. Epub 2019 Dec 30.

Bigelow TA, Thomas CL, Wu H, Itani KMF. Histotripsy Treatment of S. Aureus Biofilms on Surgical Mesh Samples Under Varying Pulse Durations. IEEE Trans Ultrason Ferroelectr Freq Control. 2017 Oct;64(10):1420-1428. doi: 10.1109/TUFFC.2017.2718841. Epub 2017 Jun 22.

Wardlow R, Bing C, VanOsdol J, Maples D, Ladouceur-Wodzak M, Harbeson M, Nofiele J, Staruch R, Ramachandran A, Malayer J, Chopra R, Ranjan A. Targeted antibiotic delivery using low temperature-sensitive liposomes and magnetic resonance-guided high-intensity focused ultrasound hyperthermia. Int J Hyperthermia. 2016 May;32(3):254-64. doi: 10.3109/02656736.2015.1134818. Epub 2016 Feb 18.

Iqbal K, Ohl SW, Khoo BC, Neo J, Fawzy AS. Effect of high-intensity focused ultrasound on Enterococcus faecalis planktonic suspensions and biofilms. Ultrasound Med Biol. 2013 May;39(5):825-33. doi: 10.1016/j.ultrasmedbio.2012.12.006. Epub 2013 Feb 27.

Xu J, Bigelow TA, Halverson LJ, Middendorf JM, Rusk B. Minimization of treatment time for in vitro 1.1 MHz destruction of Pseudomonas aeruginosa biofilms by high-intensity focused ultrasound. Ultrasonics. 2012 Jul;52(5):668-75. doi: 10.1016/j.ultras.2012.01.013. Epub 2012 Feb 1.

Bigelow TA, Northagen T, Hill TM, Sailer FC. The destruction of Escherichia coli biofilms using high-intensity focused ultrasound. Ultrasound Med Biol. 2009 Jun;35(6):1026-31. doi: 10.1016/j.ultrasmedbio.2008.12.001. Epub 2009 Jan 25.

Click here for additional references from PubMed.

]]> Lipoma https://www.fusfoundation.org/diseases-and-conditions/lipoma/ Wed, 08 Dec 2021 14:23:00 +0000 https://fusfoundation.org/?post_type=sw_disease_condition&p=3264 Focused Ultrasound Therapy

Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with lipomas that need to be removed. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue.

How it Works
Where the beams converge, focused ultrasound produces precise ablation (thermal destruction of tissue) enabling lipoma removal to be accomplished without surgery.

Advantages
The primary option for treatment of lipomas that require removal is invasive surgery.

For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications – such as surgical wound healing or infection – at a lower cost. It can reach the desired target without damaging surrounding tissue and is repeatable, if necessary.

Clinical Trials

At the present time, there are no clinical trials recruiting patients for focused ultrasound removal of lipomas.

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here, it will take you to the latest information available from https://www.clinicaltrials.gov/.

Find a Treatment Site

Search for a treatment center or clinical trial near you.

Regulatory Approval and Reimbursement 

Removing lipomas with focused ultrasound is not yet approved by regulatory bodies or covered by medical insurance companies.

Notable Papers

Pham TT, Stokolosa AM, Borden PA, Hansen KD, Hong EM, Krasieva TB, Sivoraphonh RH, Moy WJ, Heidari AE, Lee LH, Kim EH, Sun CH, Jia W, Mo J-, Kim S, Hill MG, Wong BJF. Electrochemical degradation and saponification of porcine adipose tissue. Sci Rep. 2020 Nov 27;10(1):20745. doi: 10.1038/s41598-020-76678-y.

Nguyen TT. Plastic Surgery and Cosmetic Procedures: Liposuction and Nonsurgical Fat Reduction Procedures. FP Essent. 2020 Oct;497:23-26.

Atiyeh BS, Chahine F. Evidence-Based Efficacy of High-Intensity Focused Ultrasound (HIFU) in Aesthetic Body Contouring. Aesthetic Plast Surg. 2021 Apr;45(2):570-578. doi: 10.1007/s00266-020-01863-3. Epub 2020 Jul 23.

Fonseca VM, Campos PS, Certo TF, de-Faria LT, Juliano PB, Cintra DE, Liebano RE, da Silva C, Guidi RM, Sant’Ana E. Efficacy and safety of noninvasive focused ultrasound for treatment of subcutaneous adiposity in healthy women. J Cosmet Laser Ther. 2018 Oct;20(6):341-350. doi: 10.1080/14764172.2018.1511907. Epub 2018 Oct 4.

Click here for additional references from PubMed.

]]> Dercum’s Disease https://www.fusfoundation.org/diseases-and-conditions/dercums-disease/ Wed, 08 Dec 2021 14:22:00 +0000 https://fusfoundation.org/?post_type=sw_disease_condition&p=3252 Focused Ultrasound Therapy

Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with Dercum’s disease which is also known as “Adiposis Dolorosa” which translates to “painful fat”. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue.

How it Works
Where the beams converge, focused ultrasound produces precise ablation (thermal destruction of tissue) enabling Dercum’s disease to be treated without surgery.

Advantages
The primary options for treatment of Dercum’s disease include pain medication and invasive surgery.

For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications – such as surgical wound healing or infection – at a lower cost. It can reach the desired target without damaging surrounding tissue and is repeatable, if necessary.

Clinical Trials

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of Dercum’s disease.

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here, it will take you to the latest information available from https://www.clinicaltrials.gov/. 

Find a Treatment Site

Search for a treatment center or clinical trial near you.

Regulatory Approval and Reimbursement

Focused ultrasound treatment for Dercum’s disease is not yet approved by regulatory bodies or covered by medical insurance companies.

Notable Papers

Shemer A1, Brawer S, Amichi B, Azhari H. Noninvasive lipoma size reduction using high-intensity focused ultrasound. Dermatol Surg. 2013 Oct;39(10):1446-51. doi: 10.1111/dsu.12269. Epub 2013 Jul 18.

Singal, A., Janiga, J., Bossenbroek, N. and Lim, H. (2007), Dercum’s disease (adiposis dolorosa): a report of improvement with infliximab and methotrexate. Journal of the European Academy of Dermatology and Venereology, 21: 717. doi:10.1111/j.1468-3083.2006.02021

Click here for additional references from PubMed.

]]> Hemophilia https://www.fusfoundation.org/diseases-and-conditions/hemophilia/ Wed, 08 Dec 2021 14:22:00 +0000 https://fusfoundation.org/?post_type=sw_disease_condition&p=3255 Focused Ultrasound Therapy

Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with hemophilia B, also known as Christmas Disease or Factor IX Deficiency. Similar work is being done with Hemophilia A. This novel technology focuses beams of ultrasound energy precisely and accurately on targets in the liver.

How it Works
Where the beams converge, focused ultrasound enables the release of gene-expressing vectors (in Hemophilia B) and non-viral genes (Hemophilia A), without damaging surrounding normal tissue. This preclinical work will be important in the development of future human trials.

Advantages
For certain patients, focused ultrasound could provide a noninvasive alternative treatment with less risk of complications – such as surgical wound healing or infection – at a lower cost. It can reach the desired target without damaging surrounding tissue and is repeatable, if necessary.

Clinical Trials

At the present time, there are no clinical trials recruiting patients for focused ultrasound enhancement of gene-expression vectors to treat Hemophilia.

Regulatory Approval and Reimbursement

Focused ultrasound treatment for enhancing the gene-expression treatment for Hemophilia is not yet approved by regulatory bodies or covered by medical insurance companies.

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here, it will take you to the latest information available from https://www.clinicaltrials.gov/. 

Notable Papers

Lo WS, Sheen JM, Chen YC, Wu KT, Wang LY, Lau YC, Hsiao CC, Ko JY. The Application of Focused Medium-Energy Extracorporeal Shockwave Therapy in Hemophilic A Arthropathy. Healthcare (Basel). 2022 Feb 11;10(2):352. doi: 10.3390/healthcare10020352.

Tran DM, Zhang F, Morrison KP, Loeb KR, Harrang J, Kajimoto M, Chavez F, Wu L, Miao CH. Transcutaneous Ultrasound-Mediated Nonviral Gene Delivery to the Liver in a Porcine Model. Mol Ther Methods Clin Dev Jul 26 2019; 14:275-284. doi: 10.1016/j.omtm.2019.07.005.

High Intensity Focused Ultrasound for Hepatic Gene Transfer. Presentation by Cynthia Anderson, PhD. 2018

Click here for additional references from PubMed.

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