{"id":23425,"date":"2023-12-08T11:47:34","date_gmt":"2023-12-08T15:47:34","guid":{"rendered":"https:\/\/www.fusfoundation.org\/?post_type=sw_disease_condition&#038;p=23425"},"modified":"2025-06-05T10:50:47","modified_gmt":"2025-06-05T14:50:47","slug":"dental-tissue-demineralization","status":"publish","type":"sw_disease_condition","link":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/","title":{"rendered":"Dental Tissue Demineralization"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-focused-ultrasound-therapy\">Focused Ultrasound Therapy<\/h2>\n\n\n\n<p>Focused ultrasound is a therapeutic technology that could transform the quality of life and decrease the cost of care for patients with patients suffering from dental tissue demineralization. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging the surrounding normal tissue.<\/p>\n\n\n\n<p><strong>How it Works<\/strong><br>Where the beams converge, focused ultrasound produces several therapeutic effects that are being evaluated. One of those is the ability for focused ultrasound to clean the tissue without acids or other destructive items that can worsen the demineralization of the tissues. Recent work has also used focused ultrasound in a model that includes calcium-phosphate or hydroxyapatite nanoparticles to show an increased recovery to demineralized tissue.&nbsp; While significant work has been accomplished, there is still much to be done before this technology will be widely available.<\/p>\n\n\n\n<p>The primary options for treatment of demineralization are limited, and the dentist has to weigh the benefits of using acids or other destructive items to adequately clean the tissue against the worsening effects on the mineralization of the tissue.<\/p>\n\n\n\n<p><strong>Advantages<\/strong><br>For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications \u2013 such as like surgical wound healing or infection \u2013 at a lower cost. Focused ultrasound can reach the desired target without damaging surrounding tissue, and it can be repeated, if necessary. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials\">Clinical Trials<\/h2>\n\n\n\n<p>At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of dental tissue demineralization.<\/p>\n\n\n\n<p>The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click <a href=\"https:\/\/clinicaltrials.gov\/search?cond=dermal%20tissue%20remineralization&amp;term=focused%20ultrasound&amp;aggFilters=status:not%20rec\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>here<\/strong><\/a>, it will take you to the latest information available from <a href=\"https:\/\/www.clinicaltrials.gov\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/www.clinicaltrials.gov\/<\/strong><\/a>.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-regulatory-approval-and-reimbursement\">Regulatory Approval and Reimbursement<\/h2>\n\n\n\n<p>Focused ultrasound treatment for dental tissue demineralization is not yet approved by regulatory bodies or covered by medical insurance companies.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-notable-papers\">Notable Papers<\/h2>\n\n\n\n<p>Shrestha B, Rajan SM, Saunders M, Fawzy A. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40108508\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Potential of High-Intensity Focused Ultrasound in Enamel Remineralization<\/strong><\/a>. J Dent Res. 2025 Mar 19:220345251323869. doi: 10.1177\/00220345251323869. PMID: 40108508\u00a0<\/p>\n\n\n\n<p>Rajan SM, Shrestha B, Fawzy A. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39780194\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>High-intensity focused ultrasound: an innovative approach for micro-manipulation of demineralized dentine<\/strong><\/a>. J Transl Med. 2025 Jan 8;23(1):29. doi: 10.1186\/s12967-024-06008-7. PMID: 39780194&nbsp;<\/p>\n\n\n\n<p>Shrestha B, Maria Rajan S, Aati S, Yusiharni E, Kujan O, Saunders M, Fawzy A.<strong> <a class=\"ek-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38859951\/\" target=\"_blank\" rel=\"noreferrer noopener\">The Synergistic Effect of High Intensity Focused Ultrasound on In-vitro Remineralization of Tooth Enamel by Calcium Phosphate Ion Clusters<\/a><\/strong>. Int J Nanomedicine. 2024 Jun 6;19:5365-5380. doi: 10.2147\/IJN.S464998. eCollection 2024. PMID: 38859951&nbsp;<\/p>\n\n\n\n<p>Tran MD, Ngo H, Fawzy A. <a class=\"ek-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38609759\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>High-Intensity Focused Ultrasound in Dentistry: A Literature Review<\/strong><\/a>. Int Dent J. 2024 Apr 11:S0020-6539(24)00060-1. doi: 10.1016\/j.identj.2024.02.004. PMID: 38609759&nbsp;<\/p>\n\n\n\n<p>Daood U, Fawzy AS. <a aria-label=\" (opens in a new tab)\" class=\"ek-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32008748\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Minimally invasive&nbsp;high-intensity&nbsp;focused&nbsp;ultrasound&nbsp;(HIFU) improves dentine remineralization with hydroxyapatite nanorods<\/strong><\/a>. Dent Mater. 2020 Mar;36(3):456-467. doi: 10.1016\/j.dental.2020.01.005. Epub 2020 Jan 31. PMID:&nbsp;32008748<\/p>\n\n\n\n<p>Fawzy AS, Daood U, Matinlinna JP. <a aria-label=\" (opens in a new tab)\" class=\"ek-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31003759\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Potential of&nbsp;high-intensity&nbsp;focused&nbsp;ultrasound&nbsp;in resin-dentine bonding<\/strong><\/a>. Dent Mater. 2019 Jul;35(7):979-989. doi: 10.1016\/j.dental.2019.04.001. Epub 2019 Apr 16. PMID:&nbsp;31003759<\/p>\n\n\n\n<p><a aria-label=\" (opens in a new tab)\" class=\"ek-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28%22focused+ultrasound%22+OR+HIFU%29+and+%22demineralization%22&amp;sort=date\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Click here<\/strong><\/a><strong> for additional references from PubMed.&nbsp;<\/strong><\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"sw_disease_condition_cat":[21],"sw_disease_condition_stage":[14],"class_list":["post-23425","sw_disease_condition","type-sw_disease_condition","status-publish","hentry","sw_disease_condition_cat-gastrointestinal"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Dental Tissue Demineralization - Focused Ultrasound Foundation<\/title>\n<meta name=\"description\" content=\"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Dental Tissue Demineralization\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dental Tissue Demineralization - Focused Ultrasound Foundation\" \/>\n<meta property=\"og:description\" content=\"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Dental Tissue Demineralization\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/\" \/>\n<meta property=\"og:site_name\" content=\"Focused Ultrasound Foundation\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-05T14:50:47+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/\",\"url\":\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/\",\"name\":\"Dental Tissue Demineralization - Focused Ultrasound Foundation\",\"isPartOf\":{\"@id\":\"https:\/\/www.fusfoundation.org\/#website\"},\"datePublished\":\"2023-12-08T15:47:34+00:00\",\"dateModified\":\"2025-06-05T14:50:47+00:00\",\"description\":\"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Dental Tissue Demineralization\",\"breadcrumb\":{\"@id\":\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.fusfoundation.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Dental Tissue Demineralization\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.fusfoundation.org\/#website\",\"url\":\"https:\/\/www.fusfoundation.org\/\",\"name\":\"Focused Ultrasound Foundation\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.fusfoundation.org\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.fusfoundation.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.fusfoundation.org\/#organization\",\"name\":\"Focused Ultrasound Foundation\",\"url\":\"https:\/\/www.fusfoundation.org\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.fusfoundation.org\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/cdn.fusfoundation.org\/2023\/08\/24140306\/focused-ultrasound-foundation-logo.png\",\"contentUrl\":\"https:\/\/cdn.fusfoundation.org\/2023\/08\/24140306\/focused-ultrasound-foundation-logo.png\",\"width\":730,\"height\":76,\"caption\":\"Focused Ultrasound Foundation\"},\"image\":{\"@id\":\"https:\/\/www.fusfoundation.org\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Dental Tissue Demineralization - Focused Ultrasound Foundation","description":"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Dental Tissue Demineralization","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/","og_locale":"en_US","og_type":"article","og_title":"Dental Tissue Demineralization - Focused Ultrasound Foundation","og_description":"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Dental Tissue Demineralization","og_url":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/","og_site_name":"Focused Ultrasound Foundation","article_modified_time":"2025-06-05T14:50:47+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/","url":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/","name":"Dental Tissue Demineralization - Focused Ultrasound Foundation","isPartOf":{"@id":"https:\/\/www.fusfoundation.org\/#website"},"datePublished":"2023-12-08T15:47:34+00:00","dateModified":"2025-06-05T14:50:47+00:00","description":"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Dental Tissue Demineralization","breadcrumb":{"@id":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/dental-tissue-demineralization\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.fusfoundation.org\/"},{"@type":"ListItem","position":2,"name":"Dental Tissue Demineralization"}]},{"@type":"WebSite","@id":"https:\/\/www.fusfoundation.org\/#website","url":"https:\/\/www.fusfoundation.org\/","name":"Focused Ultrasound Foundation","description":"","publisher":{"@id":"https:\/\/www.fusfoundation.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.fusfoundation.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.fusfoundation.org\/#organization","name":"Focused Ultrasound Foundation","url":"https:\/\/www.fusfoundation.org\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.fusfoundation.org\/#\/schema\/logo\/image\/","url":"https:\/\/cdn.fusfoundation.org\/2023\/08\/24140306\/focused-ultrasound-foundation-logo.png","contentUrl":"https:\/\/cdn.fusfoundation.org\/2023\/08\/24140306\/focused-ultrasound-foundation-logo.png","width":730,"height":76,"caption":"Focused Ultrasound Foundation"},"image":{"@id":"https:\/\/www.fusfoundation.org\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/sw_disease_condition\/23425","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/sw_disease_condition"}],"about":[{"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/types\/sw_disease_condition"}],"version-history":[{"count":3,"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/sw_disease_condition\/23425\/revisions"}],"predecessor-version":[{"id":35315,"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/sw_disease_condition\/23425\/revisions\/35315"}],"wp:attachment":[{"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/media?parent=23425"}],"wp:term":[{"taxonomy":"sw_disease_condition_cat","embeddable":true,"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/sw_disease_condition_cat?post=23425"},{"taxonomy":"sw_disease_condition_stage","embeddable":true,"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/sw_disease_condition_stage?post=23425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}