{"id":261,"date":"2021-12-08T19:50:00","date_gmt":"2021-12-08T19:50:00","guid":{"rendered":"https:\/\/fusfoundation.org\/?post_type=sw_disease_condition&#038;p=261"},"modified":"2026-05-13T18:29:21","modified_gmt":"2026-05-13T22:29:21","slug":"kidney-disease","status":"publish","type":"sw_disease_condition","link":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/kidney-disease\/","title":{"rendered":"Kidney Disease"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-focused-ultrasound-therapy\">Focused Ultrasound Therapy<\/h2>\n\n\n\n<p>Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with kidney disease. This novel technology focuses beams of ultrasound energy precisely and accurately on targets in the kidney.<\/p>\n\n\n\n<p><strong>How it Works<\/strong><br>Where the beams converge, focused ultrasound is being used to improve the homing and implantation of mesenchymal stem cells in the diseased kidney. Preclinical results show improved renal cell survival compared to controls. While early work is promising, there is still&nbsp;much to be done before this technology will be widely available.<\/p>\n\n\n\n<p><strong>Advantages<\/strong><br>The primary options for treatment of kidney disease include medication, dialysis and potentially invasive surgery.<\/p>\n\n\n\n<p>For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications \u2013 such as surgical wound healing or infection \u2013 at a lower cost. It can reach the desired target without damaging surrounding tissue and is repeatable, if necessary.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials\">Clinical Trials<\/h2>\n\n\n\n<p>At the present time, there are no clinical trials recruiting patients for focused treatment of kidney disease.<\/p>\n\n\n\n<p>The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click <a href=\"https:\/\/clinicaltrials.gov\/search?cond=Acute%20Kidney%20Disease&amp;term=focused%20ultrasound&amp;aggFilters=status:not%20rec\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>here<\/strong><\/a>, it will take you to the latest information available from <a href=\"https:\/\/www.clinicaltrials.gov\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/www.clinicaltrials.gov\/<\/strong><\/a>.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.fusfoundation.org\/the-technology\/research-sites\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>See a list of laboratory research sites &gt;<\/strong><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-find-a-treatment-site\">Find a Treatment Site<\/h2>\n\n\n\n<p><strong><a href=\"https:\/\/www.fusfoundation.org\/the-technology\/treatment-sites\/?indication=Kidney%20Disease%2C%20Acute\" target=\"_blank\" rel=\"noreferrer noopener\">Search for a treatment center or clinical trial near you.<\/a><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-regulatory-approval-and-reimbursement\">Regulatory Approval and Reimbursement<\/h2>\n\n\n\n<p>Focused ultrasound treatment for kidney disease is not yet approved by regulatory bodies or covered by medical insurance companies.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-notable-papers\">Notable Papers<\/h2>\n\n\n\n<p>Guo Y, Wang Y, Wang B, Peng S, Li N, Zhang D, Wu H.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41481962\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Ultrasound-responsive renal-targeted nanoparticles deliver TAK-242 to inhibit NF-\u03baB\/NLRP3 signaling and attenuate sepsis-associated acute kidney injury<\/strong><\/a>. Biomaterials. 2026\u00a0Jun;329:123922.\u00a0doi: 10.1016\/j.biomaterials.2025.123922.\u00a0Epub\u00a02025 Dec 14. PMID: 41481962\u00a0<\/p>\n\n\n\n<p>Kisting AL, Zlevor AM, Falk KL, Kisting MA, Laklouk IA, Wagner MG, White JK, Winterholler JE, Jentink M, Abel EJ, Knavel Koepsel EM, Hinshaw JL, Swietlik JF, Mao L, Minesinger GM, Laeseke PF, Ziemlewicz TJ, Lee FT Jr. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39662616\/\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"ek-link\"><strong>Histotripsy of the Proximal Ureter and Renal Pelvis: Evaluation of Urothelial Injury in a Porcine Survival Model<\/strong><\/a>. J Vasc Interv Radiol. 2024 Dec 9:S1051-0443(24)00752-8. doi: 10.1016\/j.jvir.2024.11.028. PMID: 39662616&nbsp;<\/p>\n\n\n\n<p>Couillard AB, Zlevor AM, Ziemlewicz TJ, Kisting MA, Knott E, Rossebo AE, White J, Lubner MG, Gettle LM, Hinshaw JL, Mao L, Stoffregen W, Swietlik JF, Knavel-Koepsel E, Stratchko L, Abel EJ, Xu Z, Lee FT Jr, Laeseke PF. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37481064\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>A Comparison of Histotripsy and Percutaneous Cryoablation in a Chronic Healthy Swine Kidney Model<\/strong><\/a>. J Vasc Interv Radiol. 2023 Nov;34(11):1986-1996. doi: 10.1016\/j.jvir.2023.07.014. Epub 2023 Jul 20. PMID: 37481064&nbsp;<\/p>\n\n\n\n<p>Camafort M, Ihm SH, Ruilope LM. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37706512\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong><\/strong><strong>Renal denervation for the treatment of hypertension and kidney disease<\/strong><\/a>. Curr Opin Nephrol Hypertens. 2023 Nov 1;32(6):544-550. doi: 10.1097\/MNH.0000000000000928. Epub 2023 Sep 13. PMID: 37706512&nbsp;<\/p>\n\n\n\n<p><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=(%22focused+ultrasound%22+OR+HIFU)+and+%22kidney+injury%22\" target=\"_blank\" rel=\"noreferrer noopener\">Click here<\/a> for additional references from PubMed.<\/strong><\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":false,"_editorskit_reading_time":2,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"sw_disease_condition_cat":[18],"sw_disease_condition_stage":[14],"class_list":["post-261","sw_disease_condition","type-sw_disease_condition","status-publish","hentry","sw_disease_condition_cat-urological"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - 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