{"id":2818,"date":"2021-12-08T20:05:00","date_gmt":"2021-12-08T20:05:00","guid":{"rendered":"https:\/\/fusfoundation.org\/?post_type=sw_disease_condition&#038;p=2818"},"modified":"2025-04-15T09:40:41","modified_gmt":"2025-04-15T13:40:41","slug":"hypoplastic-left-heart-syndrome","status":"publish","type":"sw_disease_condition","link":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/hypoplastic-left-heart-syndrome\/","title":{"rendered":"Hypoplastic Left Heart Syndrome"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-focused-ultrasound-therapy\">Focused Ultrasound Therapy<\/h2>\n\n\n\n<p>Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with hypoplastic left heart syndrome. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue.&nbsp;<\/p>\n\n\n\n<p><strong>How it Works<\/strong><br>Where the beams converge, the focused ultrasound produces precise ablation (either thermal or mechanical destruction of tissue) which produces an atrial septal defect. This allows pulmonary venous blood returning to the left heart to be shunted to the right heart, which improves blood flow.<br><br>An important treatment component is ensuring adequate patency of an atrial septal defect which allows pulmonary venous blood returning to the left heart to be shunted to the right heart. Focused ultrasound is capable of precise mechanical tissue destruction through a process known as histotripsy, and a preclinical study has already demonstrated the ability of histotripsy to noninvasively create an atrial septal defect.<\/p>\n\n\n\n<p><strong>Advantages<\/strong><br>The primary options for treatment of hypoplastic left heart syndrome are surgical.<br><br>For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications \u2013 such as surgical wound healing or infection \u2013 at a lower cost for certain aspects of treatment. Focused ultrasound can also reach the desired target without damaging surrounding tissue, and it can be repeated, if necessary.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials\">Clinical Trials<\/h2>\n\n\n\n<p>At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of hypoplastic left heart syndrome.<\/p>\n\n\n\n<p>The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click <a href=\"https:\/\/clinicaltrials.gov\/search?cond=Hypoplastic%20Left%20Heart%20Syndrome&amp;term=focused%20ultrasound&amp;aggFilters=status:not%20rec\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>here<\/strong><\/a>, it will take you to the latest information available from <a href=\"https:\/\/www.clinicaltrials.gov\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/www.clinicaltrials.gov\/<\/strong><\/a>.\u00a0<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-regulatory-approval-and-reimbursement\">Regulatory Approval and Reimbursement<\/h2>\n\n\n\n<p>Focused ultrasound treatment for hypoplastice left heart syndrome is not yet approved by regulatory bodies or covered by medical insurance companies.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-notable-papers\">Notable Papers<\/h2>\n\n\n\n<p>Villemain O, Kwiecinski W, Bel A, Robin J, Bruneval P, Arnal B, Tanter M, Pernot M, Messas E.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27522080\" target=\"_blank\" rel=\"noreferrer noopener\">Pulsed cavitational ultrasound for non-invasive chordal cutting guided by real-time 3D echocardiography.&nbsp;<\/a>Eur Heart J Cardiovasc Imaging. 2016 Oct;17(10):1101-7. doi: 10.1093\/ehjci\/jew145. Epub 2016 Aug 12.<\/p>\n\n\n\n<p>Devanagondi R1, Zhang X2, Xu Z3, Ives K4, Levin A5, Gurm H6, Owens GE7.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25952642\" target=\"_blank\" rel=\"noreferrer noopener\">Hemodynamic and Hematologic Effects of Histotripsy of Free-Flowing Blood: Implications for Ultrasound-Mediated Thrombolysis.<\/a>&nbsp;J Vasc Interv Radiol. 2015 Oct;26(10):1559-65. doi: 10.1016\/j.jvir.2015.03.022. Epub 2015 May 4.<\/p>\n\n\n\n<p>M. Azmin, C. Harfield, Z. Ahmad, M. Edirisinghe, and E. Stride, \u201c<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22352768\" target=\"_blank\" rel=\"noreferrer noopener\">How do microbubbles and ultrasound interact? Basic physical, dynamic and engineering principles.<\/a>,\u201d Curr. Pharm. Des., vol. 18, no. 15, pp. 2118\u20132134, 2012.<\/p>\n\n\n\n<p>Owens GE, Miller RM, Owens ST, Swanson SD, Ives K, Ensing G, Gordon D, Xu Z.&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21910018\" target=\"_blank\" rel=\"noreferrer noopener\">Intermediate-term effects of intracardiac communications created noninvasively by therapeutic ultrasound (histotripsy) in a porcine model.<\/a>&nbsp;Pediatr Cardiol. 2012 Jan;33(1):83-9. doi: 10.1007\/s00246-011-0094-6. Epub 2011 Sep 11. PubMed PMID:21910018.<\/p>\n\n\n\n<p>Xu Z, Owens G, Gordon D, Cain C, Ludomirsky A.&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20124126\" target=\"_blank\" rel=\"noreferrer noopener\">Noninvasive creation of an atrial septal defect by histotripsy in a canine model.&nbsp;<\/a>Circulation. 2010 Feb16;121(6):742-9. doi: 10.1161\/CIRCULATIONAHA.109.889071. Epub 2010 Feb 1. PubMed PMID: 20124126; PubMed Central PMCID: PMC2834201.<br><br>W. W. Roberts, T. L. Hall, K. Ives, J. S. Wolf Jr., J. B. Fowlkes, and C. A. Cain, \u201c<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16407041\" target=\"_blank\" rel=\"noreferrer noopener\">Pulsed cavitational ultrasound: A noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney<\/a>,\u201d J. Urol., vol. 175, no. 2, pp. 734\u2013738, 2006.<br><\/p>\n\n\n\n<p><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=(%22focused+ultrasound%22+OR+HIFU)+and+%22heart%22\" target=\"_blank\" rel=\"noreferrer noopener\">Click here<\/a> for additional references from PubMed.\u00a0<\/strong><\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"sw_disease_condition_cat":[5],"sw_disease_condition_stage":[14],"class_list":["post-2818","sw_disease_condition","type-sw_disease_condition","status-publish","hentry","sw_disease_condition_cat-cardiovascular"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - 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