{"id":2821,"date":"2021-12-08T20:06:00","date_gmt":"2021-12-08T20:06:00","guid":{"rendered":"https:\/\/fusfoundation.org\/?post_type=sw_disease_condition&p=2821"},"modified":"2025-09-04T14:57:32","modified_gmt":"2025-09-04T18:57:32","slug":"mitral-valve-regurgitation","status":"publish","type":"sw_disease_condition","link":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/mitral-valve-regurgitation\/","title":{"rendered":"Mitral Valve Regurgitation\u00a0"},"content":{"rendered":"\n

Focused Ultrasound Therapy<\/h2>\n\n\n\n

Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with mitral regurgitation (MR). This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue.<\/p>\n\n\n\n

How it Works<\/strong>
Where the beams converge, the focused ultrasound produces precise ablation (thermal destruction) of the central basal chordae, a structure which normally supports the mitral valve but can result in regurgitant blood flow after an infarction. The planned result is that cutting this structure can improve the function of the mitral valve. This work has been done in a preclinical setting, but further research will be needed before it is available for treating humans.<\/p>\n\n\n\n

Advantages<\/strong>
The primary options for treatment of MR includes medication or invasive surgical procedures.<\/p>\n\n\n\n

For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications \u2013 such as surgical wound healing or infection \u2013 at a lower cost. The noninvasive approach can be especially valuable since the patients may have recently had a myocardial infarction. Focused ultrasound can also reach the desired target without damaging surrounding tissue, and it can be repeated, if necessary.<\/strong><\/p>\n\n\n\n

Clinical Trials<\/h2>\n\n\n\n

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of MR.<\/p>\n\n\n\n

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here<\/strong><\/a>, it will take you to the latest information available from https:\/\/www.clinicaltrials.gov\/<\/strong><\/a>.\u00a0<\/p>\n\n\n\n

Regulatory Approval and Reimbursement<\/h2>\n\n\n\n

Focused ultrasound treatment for MR is not yet approved by regulatory bodies or covered by medical insurance companies.<\/p>\n\n\n\n

Notable Papers<\/h2>\n\n\n\n

Villemain O, Kwiecinski W, Bel A, Robin J, Bruneval P, Arnal B, Tanter M, Pernot M, Messas M. Pulsed cavitational ultrasound for non-invasive chordal cutting guided by real-time 3D echocardiography.<\/a> Eur Heart J Cardiovasc Imaging. 2016 Oct;17(10):1101-7. doi: 10.1093\/ehjci\/jew145. Epub 2016 Aug 12.

Abe Y, Otsuka R, Muratore R, Fujikura K, Okajima K, Suzuki K, Wang J, Marboe C, Kalisz A, Ketterling JA, Lizzi FL, Homma S. In vitro mitral chordal cutting by high intensity focused ultrasound. <\/a>Ultrasound Med Biol. 2008 Mar;34(3):400-5. Epub 2007 Nov 7.<\/p>\n\n\n\n

Click here<\/a>\u00a0for additional references from PubMed.<\/strong><\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"sw_disease_condition_cat":[5],"sw_disease_condition_stage":[14],"class_list":["post-2821","sw_disease_condition","type-sw_disease_condition","status-publish","hentry","sw_disease_condition_cat-cardiovascular"],"acf":[],"yoast_head":"\nMitral Valve Regurgitation\u00a0 - Focused Ultrasound Foundation<\/title>\n<meta name=\"description\" content=\"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Mitral Valve Regurgitation\u00a0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/mitral-valve-regurgitation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mitral Valve Regurgitation\u00a0 - 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