{"id":2876,"date":"2021-12-08T20:27:00","date_gmt":"2021-12-08T20:27:00","guid":{"rendered":"https:\/\/fusfoundation.org\/?post_type=sw_disease_condition&p=2876"},"modified":"2025-08-22T15:39:37","modified_gmt":"2025-08-22T19:39:37","slug":"irritable-bowel-syndrome","status":"publish","type":"sw_disease_condition","link":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/irritable-bowel-syndrome\/","title":{"rendered":"Irritable Bowel Syndrome"},"content":{"rendered":"\n

Focused Ultrasound Therapy<\/h2>\n\n\n\n

Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with irritable bowel syndrome. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue.<\/p>\n\n\n\n

How it Works<\/strong>
Where the beams converge, focused ultrasound produces neuromodulation of the nervous tissue that regulates the bowel, potentially enabling irritable bowel syndrome to be treated without surgery. There is also a group in Egypt that is using HIFU with cavitation and vibrations to help elevate the tissue temperature and produce rapid cell necrosis in the targeted tissues. While significant preclinical work has been accomplished, there is still much to be done before this technology will be widely available.<\/p>\n\n\n\n

Advantages<\/strong>
The primary options for treatment of irritable bowel syndrome include medication, which is often ineffective.

For certain patients, focused ultrasound could provide a non-invasive alternative that may be more effective that conventional treatments.\u00a0Focused ultrasound can reach the desired target without damaging surrounding tissue, and can also be repeated, if necessary.\u00a0Focused ultrasound use and\/or neuromodulation does not appear to have the side effects commonly found with systemic medications.<\/p>\n\n\n\n

Clinical Trials<\/h2>\n\n\n\n

A clinical trial<\/strong><\/a> in Egypt is using focused ultrasound with cavitation to treat patients with Inflammatory Bowel Syndrome.\u00a0<\/p>\n\n\n\n

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here<\/strong><\/a>, it will take you to the latest information available from https:\/\/www.clinicaltrials.gov\/<\/strong><\/a>.\u00a0<\/p>\n\n\n\n

Regulatory Approval and Reimbursement<\/h2>\n\n\n\n

Focused ultrasound treatment for irritable bowel syndrome is not yet approved by regulatory bodies or covered by medical insurance companies.<\/p>\n\n\n\n

Notable Papers<\/h2>\n\n\n\n

Jensen LJ, Loch FN, Kamphues C, Shahryari M, Marticorena Garcia SR, Siegmund B, Weidinger C, K\u00fchl AA, Hamm B, Braun J, Sack I, Asbach P, Reiter R. Feasibility of\u202fin vivo<\/em>\u202fmagnetic resonance elastography of mesenteric adipose tissue in Crohn’s disease.<\/a> Quant Imaging Med Surg. 2023 Aug 1;13(8):4792-4805. doi: 10.21037\/qims-23-41. Epub 2023 Jun 28. PMID:\u202f37581033\u202f\u00a0<\/p>\n\n\n\n

Akhtar K, Hirschstein Z, Stefanelli A, Iannilli E, et al. Non-invasive peripheral focused ultrasound neuromodulation of the celiac plexus ameliorates symptoms in a rat model of inflammatory bowel disease.<\/a> Exp Physiol. 2021 Jan 29. doi: 10.1113\/EP088848.<\/p>\n\n\n\n

Cotero V, Miwa H, Graf J, Ashe J, Loghin E, Di Carlo D, Puleo C. Periphereal Focused Ultrasound Neuromodulation. <\/a>J Neurosci Methods. 2020 Jul 15;341:108721. doi:10.1016\/j.jneumeth.2020.108721. Epub 2020 May 6.<\/p>\n\n\n\n

Click here<\/a> for additional references from PubMed.<\/strong><\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"sw_disease_condition_cat":[21],"sw_disease_condition_stage":[20],"class_list":["post-2876","sw_disease_condition","type-sw_disease_condition","status-publish","hentry","sw_disease_condition_cat-gastrointestinal"],"acf":[],"yoast_head":"\nIrritable Bowel Syndrome - Focused Ultrasound Foundation<\/title>\n<meta name=\"description\" content=\"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Irritable Bowel Syndrome\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/irritable-bowel-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Irritable Bowel Syndrome - 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