Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with bone tumors. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue.<\/p>\n\n\n\n
How it Works<\/strong> Advantages<\/strong> For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications \u2013 such as surgical wound healing or infection \u2013 at a lower cost. It can reach the desired target without damaging surrounding tissue and is repeatable, if necessary.<\/p>\n\n\n\n There is a multi-site clinical trial<\/strong><\/a> comparing the treatment of osteoid osteoma with magnetic resonance guided focused ultrasound vs. radiofrequency ablation. <\/p>\n\n\n\n There is a pediatric and young adult study underway in Washington, DC that involves the use of FUS in combination with a thermally sensitive form of liposomal doxorubicin<\/strong><\/a> on a variety of solid tumors.<\/p>\n\n\n\n There is a multisite trial<\/a><\/strong> in Europe treating patients with bone metastasis comparing focused ultrasound and radiotherapy (FURTHER).<\/p>\n\n\n\n There is a clinical trial<\/a><\/strong> in France treating bone metastatic lesions and osteoid osteoma.<\/p>\n\n\n\n There is a clinical trial<\/strong><\/a> in Taiwan using focused ultrasound to treat painful bone metastatic lesions. <\/p>\n\n\n\n There is a clinical trial<\/strong><\/a> in Switzerland using the combination of focused ultrasound and hyperthermia to treat painful bone metastatic lesions. <\/p>\n\n\n\n The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here<\/strong><\/a>, it will take you to the latest information available from https:\/\/www.clinicaltrials.gov\/<\/strong><\/a>. Search for a treatment center or clinical trial near you.<\/a><\/strong><\/p>\n\n\n\n Bone tumor treatment is approved in Europe, Russia, and China. It is not approved in the United States.<\/p>\n\n\n\n Vickers ER, Ruger LN, Coutermarsh-Ott SL, Daniel GB, Allen SP,\u00a0Ziemlewicz\u00a0TJ, Soliman SB, Malhotra GB, Maxwell AD,\u00a0Vlaisavljevich\u00a0E, Tuohy J.\u00a0MRI for the Assessment of Histotripsy Ablation in a Canine Osteosarcoma Comparative Oncology Model<\/strong><\/a>. Ultrasound Med Biol. 2025 Oct\u00a017:S0301-5629(25)00383-7.\u00a0doi: 10.1016\/j.ultrasmedbio.2025.09.017. PMID: 41109828\u00a0<\/p>\n\n\n\n Aginsky R, Leblang S, Miller E, Skoglind B, Nyska A, Rebhun N, Gofeld M, Aubry JF, Hananel A. High intensity focused ultrasound periosteal ablation in an animal model: potential for palliation of bone metastases<\/strong><\/a>. Int J Hyperthermia. 2025 Dec;42(1):2543330. doi: 10.1080\/02656736.2025.2543330. Epub 2025 Aug 7. PMID: 40775539 <\/p>\n\n\n\n Hay AN, Imran KM, Hendricks-Wenger A, Gannon JM, Sereno J, Simon A, Lopez VA, Coutermarsh-Ott S, Vlaisavljevich E, Allen IC, Tuohy JL. Ablative and Immunostimulatory Effects of Histotripsy Ablation in a Murine Osteosarcoma Model<\/strong><\/a>.<\/strong> Biomedicines. 2023 Oct 9;11(10):2737. doi: 10.3390\/biomedicines11102737. PMID: 37893110 <\/p>\n\n\n\n Napoli A, De Maio A, Alfieri G, Gasperini C, Scipione R, Campanacci L, Siepe G, De Felice F, Siniscalchi B, Chiurchioni L, Tombolini V, Donati DM, Morganti AG, Ghanouni P, Catalano C, Bazzocchi A. Focused Ultrasound and External Beam Radiation Therapy for Painful Bone Metastases: A Phase II Clinical Trial<\/strong><\/a>. Radiology. 2023 Apr;307(2):e211857. doi: 10.1148\/radiol.211857. Epub 2023 Jan 3.<\/p>\n\n\n\n Zoccali C, Novello M, Arrigoni F, Scotto di Uccio A, Attala D, Ferraresi V. Osteoblastoma: When the Treatment Is Not Minimally Invasive, an Overview<\/strong><\/a>. J Clin Med. 2021 Oct 10;10(20):4645. doi: 10.3390\/jcm10204645.<\/p>\n\n\n\n
Where the beams converge, focused ultrasound produces precise ablation (thermal destruction of tissue) enabling bone tumors to be treated without surgery. Note: there are some specific bone tumors that have their own entry into our website. For osteoid osteoma, multiple myeloma, sacral chordoma, and bone metastases, please see those separate listings.<\/p>\n\n\n\n
The primary options for treatment of bone tumors include invasive surgery.<\/p>\n\n\n\nClinical Trials<\/h2>\n\n\n\n
See a list of treatment sites ><\/a>
See a list of clinical trials sites ><\/a>
See a list of laboratory research sites ><\/a><\/strong><\/p>\n\n\n\nFind a Treatment Site<\/h2>\n\n\n\n
Regulatory Approval and Reimbursement<\/h2>\n\n\n\n
Notable Papers<\/h2>\n\n\n\n