{"id":2936,"date":"2021-12-08T20:38:00","date_gmt":"2021-12-09T00:38:00","guid":{"rendered":"https:\/\/fusfoundation.org\/?post_type=sw_disease_condition&#038;p=2936"},"modified":"2026-03-13T10:45:13","modified_gmt":"2026-03-13T14:45:13","slug":"osteoid-osteoma","status":"publish","type":"sw_disease_condition","link":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/osteoid-osteoma\/","title":{"rendered":"Osteoid Osteoma"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-focused-ultrasound-therapy\">Focused Ultrasound Therapy<\/h2>\n\n\n\n<p>The FDA has approved Profound Medical\u2019s Sonalleve device for the treatment of patients with Osteoid Osteoma. For more information on treatment site locations, please see&nbsp;<a href=\"https:\/\/profoundmedical.com\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Profound Medical\u2019s website<\/strong><\/a>.<\/p>\n\n\n\n<p>Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with osteoid osteoma. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue.<\/p>\n\n\n\n<p><strong>How it Works<\/strong><br>Where the beams converge, focused ultrasound produces precise ablation (thermal destruction of tissue) enabling osteoid osteoma to be treated without surgery.<\/p>\n\n\n\n<p><strong>Advantages<\/strong><br>The primary options for treatment of osteoid osteoma include pain medications, but some cases require invasive surgery.<\/p>\n\n\n\n<p>For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications \u2013 such as surgical wound healing or infection \u2013 at a lower cost. It can reach the desired target without damaging surrounding tissue and is repeatable, if necessary.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials\">Clinical Trials<\/h2>\n\n\n\n<p>A <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02923011?term=Focused+ultrasound&amp;cond=Osteoid+Osteoma&amp;rank=4\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>study<\/strong><\/a> has opened at the University of California in San Francisco (UCSF) and Stanford University, which is comparing MR-guided focused ultrasound treatment for osteoid osteoma to radiofrequency ablation.&nbsp;<\/p>\n\n\n\n<p>A\u202f<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04658771?term=NCT04658771&amp;draw=2&amp;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>clinical trial<\/strong><\/a>\u202fat Children\u2019s National in Washington D.C. is treating patients with painful osteoid osteoma and has completed their enrollment.\u202f.&nbsp;<\/p>\n\n\n\n<p>A <a href=\"https:\/\/clinicaltrials.gov\/ct2\/results?cond=&amp;term=NCT04803773&amp;cntry=&amp;state=&amp;city=&amp;dist=\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>clinical trial<\/strong><\/a>\u202fin France is treating patients with bone metastatic lesions or with osteoid osteoma.&nbsp;<\/p>\n\n\n\n<p>A registry, funded in part by the Foundation, has begun and will enroll more patients at additional sites worldwide. For more information, contact Simal Goman at 416-813-6456<a href=\"mailto:simal.goman@sickkids.ca\"><strong>.<\/strong><\/a><\/p>\n\n\n\n<p>The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click <a href=\"https:\/\/clinicaltrials.gov\/search?cond=Osteoid%20Osteoma&amp;term=focused%20ultrasound&amp;aggFilters=status:not%20rec\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>here<\/strong><\/a>, it will take you to the latest information available from <a href=\"https:\/\/www.clinicaltrials.gov\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/www.clinicaltrials.gov\/<\/strong><\/a>.&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-embed alignright is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"A Focused Ultrasound Patient Story: Jack (Bone Tumor)\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/GCv1WYwDf90?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p><strong><a href=\"https:\/\/www.fusfoundation.org\/the-technology\/treatment-sites\" target=\"_blank\" rel=\"noreferrer noopener\">See here for a list of treatment sites<\/a><br><a href=\"https:\/\/clinicaltrials.gov\/ct2\/results?cond=Osteoid+Osteoma&amp;term=focused+ultrasound&amp;cntry=&amp;state=&amp;city=&amp;dist=\" target=\"_blank\" rel=\"noreferrer noopener\">See here for a list of clinical trials sites<\/a><br><a href=\"https:\/\/www.fusfoundation.org\/the-technology\/research-sites\" target=\"_blank\" rel=\"noreferrer noopener\">See here for a list of laboratory research sites<\/a><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-find-a-treatment-site\">Find a Treatment Site<\/h2>\n\n\n\n<p><strong><a href=\"https:\/\/www.fusfoundation.org\/the-technology\/treatment-sites\/?indication=Osteoid%20Osteoma\" target=\"_blank\" rel=\"noreferrer noopener\">Search for a treatment center or clinical trial near you.<\/a><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-regulatory-approval-and-reimbursement\"><strong>Regulatory Approval and Reimbursement<\/strong><\/h2>\n\n\n\n<p>The Profound Medical Sonalleve is FDA approved for treatment of osteoid osteoma in the US. Chongqing Haifu Medical Technology is approved for osteoid osteoma in Europe, Russia and China. The&nbsp;<strong><a href=\"http:\/\/www.insightec.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Insightec<\/a>&nbsp;<\/strong>ExAblate Neuro is approved for treating this condition in Europe.<\/p>\n\n\n\n<p>To date, focused ultrasound is not widely reimbursed by medical insurers for treatment of osteoid osteoma.<\/p>\n\n\n\n<figure class=\"wp-block-embed alignright is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"A Focused Ultrasound Patient Story: Della (Bone Tumor)\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/u8okCDRruVg?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-notable-papers\">Notable Papers<\/h2>\n\n\n\n<p>Arrigoni F, Bruno F, Palumbo P,\u00a0Rinvenuto\u00a0L,\u00a0Muselli\u00a0M, Calbi R, Zoccali C,\u00a0Zugaro\u00a0L,\u00a0Splendiani\u00a0A, Barile A, Di Cesare E. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41341895\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) for ablation of osteoid osteoma: Long-term results from 10 years of experience<\/strong><\/a>.\u00a0Eur\u00a0J\u00a0Radiol\u00a0Open. 2025 Nov\u00a018;15:100708.\u00a0doi: 10.1016\/j.ejro.2025.100708.\u00a0eCollection\u00a02025 Dec. PMID: 41341895\u00a0<\/p>\n\n\n\n<p>Erber B, Ge\u00dfl A, Reidler P, D\u00fcrr HR, Klein A, Seidensticker M, Wildgruber M, Ricke J, Sabel B. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39753004\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Impact of reactive sclerosis on outcome of MR-HIFU for osteoid osteomas<\/strong><\/a>. Eur J Radiol. 2025 Feb;183:111902. doi: 10.1016\/j.ejrad.2024.111902. Epub 2024 Dec 26. PMID: 39753004&nbsp;<\/p>\n\n\n\n<p>Ciatawi K, Dusak IWS, Wiratnaya IGE. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38150115\/\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"ek-link\"><strong>High-intensity focused ultrasound-a needleless management for osteoid osteoma: a systematic review<\/strong><\/a>. Musculoskelet Surg. 2023 Dec 27. doi: 10.1007\/s12306-023-00801-1. PMID: 38150115&nbsp;<\/p>\n\n\n\n<p>Hu R, He P, Tian X, Guan H.\u202f<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37523874\/%22%20\/t%20%22_blank\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Efficacy and safety of magnetic resonance-guided focused ultrasound for the treatment of osteoid osteoma: A systematic review and meta-analysis<\/strong><\/a>. Eur J Radiol. 2023 Jul 22;166:111006. doi: 10.1016\/j.ejrad.2023.111006. PMID: 37523874\u202f&nbsp;<\/p>\n\n\n\n<p>Acanfora C, Grassi E, Giacobbe G, Ferrante M, Granata V, Barile A, Cappabianca S.\u202f<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35407593\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Post-Procedural Follow-Up of the Interventional Radiology\u2019s Management of Osteoid Osteomas and Osteoblastomas<\/strong><\/a><strong>.<\/strong>\u202fJ Clin Med. 2022 Apr 2;11(7):1987. doi: 10.3390\/jcm11071987.&nbsp;<\/p>\n\n\n\n<p>Parmeggiani A, Martella C, Ceccarelli L, Miceli M, Spinnato P, Facchini G.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33839926\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\u202fOsteoid osteoma: which is the best mininvasive treatment option?\u202f<\/strong><\/a>Eur J Orthop Surg Traumatol. 2021 Apr 11. doi: 10.1007\/s00590-021-02946-w.&nbsp;<\/p>\n\n\n\n<p>Arrigoni F, Spiliopoulos S, de Cataldo C, Reppas L, Palumbo P, Mazioti A, Bruno F, Zugaro L, Papakonstantinou O, Barile A, Kelekis A, Masciocchi C, Filippiadis D.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33775816\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\u202fA bicentric propensity score matching study comparing percutaneous computed tomography-guided radiofrequency Ablation to Magnetic Resonance-guided Focused Ultrasounds for the treatment of osteoid osteoma<\/strong><\/a>. J Vasc Interv Radiol. 2021 Mar 25:S1051-0443(21)00932-5. doi: 10.1016\/j.jvir.2021.03.528.&nbsp;<\/p>\n\n\n\n<p>Arrigoni F, Bruno F, Gianneramo C, Palumbo P, Zugaro L, Zoccali C, Barile A, Masciocchi C.\u202f<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32040718\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Evolution of the imaging features of osteoid osteoma treated with RFA or MRgFUS during a long-term follow-up: a pictorial review with clinical correlations<\/strong><\/a>. Radiol Med. 2020 Feb 10. doi: 10.1007\/s11547-020-01134-w.&nbsp;<\/p>\n\n\n\n<p>Arrigoni F, Napoli A, Bazzocchi A, Zugaro L, Scipione R, Bruno F, Palumbo P, Anzidei M, Mercatelli D, Gravina GL, Zoccali C, Ghanouni P, Barile A, Catalano C, Masciocchi C.\u202f<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31129699\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Magnetic-resonance-guided focused ultrasound treatment of non-spinal osteoid osteoma in children: multicentre experience<\/strong><\/a>. Pediatr Radiol. 2019 May 25. doi: 10.1007\/s00247-019-04426-0. [Epub ahead of print] PMID: 31129699&nbsp;<\/p>\n\n\n\n<p><strong><strong><a class=\"ek-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28%22focused+ultrasound%22+OR+HIFU%29+and%22osteoid+osteoma%22&amp;sort=date\" target=\"_blank\" rel=\"noreferrer noopener\">Click here<\/a>&nbsp;for additional references from PubMed.<\/strong><\/strong><\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"sw_disease_condition_cat":[25],"sw_disease_condition_stage":[15,19,20],"class_list":["post-2936","sw_disease_condition","type-sw_disease_condition","status-publish","hentry","sw_disease_condition_cat-pain-relief"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - 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