{"id":2975,"date":"2022-01-31T20:46:00","date_gmt":"2022-02-01T00:46:00","guid":{"rendered":"https:\/\/fusfoundation.org\/?post_type=sw_disease_condition&#038;p=2975"},"modified":"2026-04-06T11:21:41","modified_gmt":"2026-04-06T15:21:41","slug":"alzheimers-disease","status":"publish","type":"sw_disease_condition","link":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/alzheimers-disease\/","title":{"rendered":"Alzheimer&#8217;s Disease\u00a0"},"content":{"rendered":"\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-50 is-style-fill\"><a class=\"wp-block-button__link has-background wp-element-button\" href=\"https:\/\/www.fusfoundation.org\/the-technology\/treatment-sites\/?indication=Alzheimer%27s%20Disease\" style=\"background-color:#086da8\" target=\"_blank\" rel=\"noreferrer noopener\">Find a Treatment Site or Clinical Trial<\/a><\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-overview\">Overview<\/h2>\n\n\n\n<p>Focused ultrasound is a rapidly evolving, noninvasive therapeutic technology that is improving the quality and longevity of life and decreasing the cost of care for millions of patients with a variety of serious medical disorders. It offers a disruptive, game changing alternative or complement to surgery, radiation therapy, drug delivery, and cancer immunotherapy. This novel technology precisely focuses beams of ultrasound energy on targets deep in the body without affecting surrounding normal tissue. Where the beams converge, the ultrasound can produce a variety of therapeutic effects without incisions or radiation.<\/p>\n\n\n\n<p>For Alzheimer\u2019s disease, focused ultrasound temporarily opens the blood-brain barrier (BBB), a naturally occurring barrier of tightly aligned cells along blood vessels that normally inhibits the diffusion of medications and immune cells into the brain.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-benefits\">Benefits<\/h2>\n\n\n\n<p>Currently, there is no cure or effective treatment for Alzheimer\u2019s disease. Potentially promising drug and antibody therapies have proven ineffective due to their inability to cross the BBB and enter the brain<\/p>\n\n\n\n<p>Advantages:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Noninvasive \u2013 no incisions, no risk of infection or bleeding, less pain, and rapid recovery<\/li>\n\n\n\n<li>Image-guided \u2013 minimal damage to surrounding tissue<\/li>\n\n\n\n<li>Safe, temporary, and repetitive opening of the BBB \u2013 enhancing the delivery of therapeutics and immune cells directly to the brain target site<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-mechanisms-of-action\">Mechanisms of Action<\/h2>\n\n\n\n<p>Focused ultrasound delivers a variety of effects on tissue, and the following mechanisms are currently in use or under investigation for the treatment of Alzheimer\u2019s disease.<\/p>\n\n\n\n<p><strong><a href=\"https:\/\/www.fusfoundation.org\/the-technology\/mechanisms-of-focused-ultrasound\/#h-enhanced-therapeutic-delivery\">Enhanced Therapeutic Delivery<\/a><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Blood-Brain Barrier Opening<\/strong>: increased diffusion of therapeutics and immune cells to targeted brain tissue<\/li>\n\n\n\n<li><strong>Local release of carrier-mediated payload<\/strong>: locally activating encapsulated therapies<\/li>\n<\/ul>\n\n\n\n<p><strong><a href=\"https:\/\/www.fusfoundation.org\/the-technology\/mechanisms-of-focused-ultrasound\/#h-immune-modulation\">Immune Modulation<\/a><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Enhanced immunotherapeutic delivery and activation<\/strong>: increases tumor exposure to immunotherapies<\/li>\n\n\n\n<li><strong>Increased immune cell infiltration<\/strong>: promoting migration of immune cells into target tissue<\/li>\n<\/ul>\n\n\n\n<p><strong><a href=\"https:\/\/www.fusfoundation.org\/the-technology\/mechanisms-of-focused-ultrasound\/#h-neuromodulation\">Neuromodulation<\/a><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Excitatory\/Inhibitory modulation of neuronal activity and nerve fibers<\/strong>: altering neuronal firing and circuitry<\/li>\n<\/ul>\n\n\n\n<p><strong><a href=\"https:\/\/www.fusfoundation.org\/the-technology\/mechanisms-of-focused-ultrasound\/#h-other\">Other<\/a><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Stem cell homing<\/strong>: guiding stem cells to targeted tissue, supporting repair and regeneration<\/li>\n\n\n\n<li><strong>Glymphatic stimulation<\/strong>: enhancing the function of the brain\u2019s waste-clearing system<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-regulatory-authorizations\">Regulatory Authorizations<\/h2>\n\n\n\n<p>Europe, CE Marking (Includes all countries in the EU, plus Norway, Iceland, and Liechtenstein): NEUROLITH by Storz Medical<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials\">Clinical Trials<\/h2>\n\n\n\n<p>The following is a curated list of clinical trials exploring the use of focused ultrasound to address Alzheimer&#8217;s disease. <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07207122?term=NCT07207122%20&amp;rank=1\">Effects of Transcranial Ultrasound Stimulation (TUS) on Neurological and Cognitive Outcomes in Neurodegenerative Diseases (NDD-01)<\/a> <br>This trial in California is investigating whether transcranial ultrasound stimulation improves neurologic and cognitive outcomes in patients with neurodegenerative diseases.&nbsp;<\/li>\n\n\n\n<li><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05997030\" target=\"_blank\" rel=\"noreferrer noopener\">Low-Intensity&nbsp;Focused&nbsp;Ultrasound&nbsp;(LIFU) Neuromodulation<\/a> <br>Researchers in West Virginia are using low-intensity focused ultrasound neuromodulation in the treatment of patients with mild cognitive impairment due to Alzheimer\u2019s disease.<\/li>\n\n\n\n<li><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07239310\" target=\"_blank\" rel=\"noreferrer noopener\">Neuclare Device for Temporary Improvement of Executive Function in Patients With Mild Cognitive Impairment and Prodromal Alzheimer&#8217;s Disease <\/a><br>This trial is taking place in South Korea and is treating patients with mild cognitive impairment or early Alzheimer\u2019s disease.<\/li>\n\n\n\n<li><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03671889\">ExAblate Blood-Brain Barrier (BBB) Disruption for the Treatment of Alzheimer&#8217;s Disease<\/a> <br>This trial at sites in Florida, New York, Ohio, Texas, West Virginia is opening the BBB with MR-guided focused ultrasound in patients with Alzheimer\u2019s disease.&nbsp;<\/li>\n\n\n\n<li><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05417555\" target=\"_blank\" rel=\"noreferrer noopener\">Low Intensity&nbsp;Focused&nbsp;Ultrasound&nbsp;for Mild Cognitive Impairment and Mild&nbsp;Alzheimer&#8217;s&nbsp;Disease&nbsp;(LIFUP-MCIAD)<\/a> <br>Researchers in Los Angeles are using low-intensity focused ultrasound for early cognitive disability or Alzheimer\u2019s disease.<\/li>\n<\/ul>\n\n\n\n<p>The following clinical trials have completed enrolling patients, and results are expected soon. <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06135051\" target=\"_blank\" rel=\"noreferrer noopener\">Ultrasonic Neuromodulation for Treatment of Cognitive Impairment<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05469009\" target=\"_blank\" rel=\"noreferrer noopener\">Safety and Feasibility of Exablate Blood-Brain Barrier Disruption for Mild Cognitive Impairment or Mild Alzheimer&#8217;s Disease Undergoing Standard of Care Monoclonal Antibody (mAb) Therapy<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05983575\">A Pivotal Study of LIPUS-Brain in Patients With Early Alzheimer&#8217;s Disease&nbsp;&nbsp;<\/a><\/li>\n<\/ul>\n\n\n\n<p>The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click <a href=\"https:\/\/www.clinicaltrials.gov\/search?cond=Alzheimer%20Disease&amp;term=focused%20ultrasound&amp;aggFilters=status:not%20rec\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>here<\/strong><\/a>, it will take you to the latest information available from <a href=\"https:\/\/www.clinicaltrials.gov\/\"><strong>https:\/\/www.clinicaltrials.gov\/<\/strong><\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-preclinical-laboratory-studies\">Preclinical Laboratory Studies<\/h2>\n\n\n\n<p>The following studies are partially or fully funded by the Focused Ultrasound Foundation.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Development of a transcranial focused ultrasound system for the Alzheimer\u2019s disease (AD) transgenic pig to open blood brain barrier for stem cell therapy (Jeju National University)<\/li>\n\n\n\n<li>Enhancing Neurogenesis by Focused Ultrasound-mediated Plasmid Delivery (University of Virginia)<\/li>\n\n\n\n<li>Focused Ultrasound-Enhanced Systemic Delivery of Lipid Nanoparticles for BrainWide Gene Therapy in Alzheimer\u2019s Disease (Columbia University)<\/li>\n\n\n\n<li>Focused Ultrasound-Mediated Microglial Activation to Promote Amyloid Beta Clearance in Alzheimer&#8217;s Disease (University College London)<\/li>\n\n\n\n<li>In Vivo PET imaging of ultrasound-assisted therapies in Alzheimer\u2019s Disease (Stanford University)<\/li>\n\n\n\n<li>Promoting oligodendrogenesis with ultrasound for Alzheimer\u2019s disease: A noninvasive, non-pharmacological regenerative strategy (Sunnybrook Health Sciences Centre)<\/li>\n\n\n\n<li>Sonogenetics-enabled spatial and temporal expression of transcription factors for direct programming of human stem cells (Penn State University)<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-manufacturers\">Manufacturers<\/h2>\n\n\n\n<p>The following manufacturers are active in the field of focused ultrasound and its applications for Alzheimer&#8217;s disease.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Acoustiic, Inc. | Bellevue, WA, United States | www.acoustiic.com<\/li>\n\n\n\n<li>BrainSonix Corp. | Sherman Oaks, CA, United States | www.brainsonix.com<\/li>\n\n\n\n<li>Carthera | Paris, France | www.carthera.eu<\/li>\n\n\n\n<li>Ceretas Pty., Ltd. | Brisbane, Australia | www.ceretas.com.au<\/li>\n\n\n\n<li>Curapulse Co., Ltd | Busan, South Korea | www.cura-pulse.com<\/li>\n\n\n\n<li>Deepson Bio, Ltd. | Chuncheon-si, South Korea | www.deepsonbio.com<\/li>\n\n\n\n<li>Delsona Therapeutics, Inc. | New York, NY, United States | www.delsona.com<\/li>\n\n\n\n<li>Grey Matter Neurosciences | Toronto, ON, Canada | www.greymatterneurosciences.com<\/li>\n\n\n\n<li>MBInsight Systems | Miaoli County, Taiwan<\/li>\n\n\n\n<li>Microvascular Therapeutics, LLC | Tucson, AZ, United States | www.mvtpharma.com<\/li>\n\n\n\n<li>Neumous, Inc. | Cheongju-si, South Korea | www.neumous.com<\/li>\n\n\n\n<li>Neurosona Co., Ltd. | Seoul, South Korea | www.neurosona.com<\/li>\n\n\n\n<li>Sanmai Technologies, PBC | Los Altos, CA, United States | www.sanmai.tech<\/li>\n\n\n\n<li>Sound Wave Innovation Co., Ltd. | Tokyo, Japan | www.sw-innovation.com<\/li>\n\n\n\n<li>Storz Medical, AG | T\u00e4gerwilen, Switzerland | www.storzmedical.com<\/li>\n\n\n\n<li>Zhongke Green Valley Medical Technology Co., Ltd. | Shenzhen, China | en.gvbraintech.com<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-media-amp-videos\">Media &amp; Videos<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Webinar: Focused Ultrasound and Alzheimer&#039;s Disease\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/anxWlQfVXcc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Understanding Alzheimer&#039;s and Exploring New Frontiers in Treatment\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/31NGKKakmVs?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p><a href=\"https:\/\/www.scmp.com\/news\/china\/science\/article\/3340862\/mothers-mind-appears-restored-might-ultrasound-be-cure-alzheimers\" target=\"_blank\" rel=\"noreferrer noopener\">A Mother\u2019s Mind Appears Restored: Might Ultrasound Be a Cure For Alzheimer\u2019s?<\/a><br><em>South China Morning Post \u2013 January 23, 2026<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.nytimes.com\/2024\/01\/10\/health\/blood-brain-barrier-alzheimers-ultrsound.html\" target=\"_blank\" rel=\"noreferrer noopener\">An Ultrasound Experiment Tackles a Giant Problem in Brain Medicine<\/a><br><em>New York Times \u2013 January 10, 2024<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/wvumedicine.org\/news\/article\/WVU-Medicine\/Front-Page\/breakthrough-in-treating-alzheimer-s-using-targeted-drug-delivery-reported-in-new-england-journal-of-medicine\/\" target=\"_blank\" rel=\"noreferrer noopener\">Breakthrough in Treating Alzheimer\u2019s Using Targeted Drug Delivery Reported in <em>New England Journal of Medicine<\/em><\/a><br><em>West Virginia University Medicine \u2013 January 3, 2024<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.sciencefocus.com\/news\/ultrasound-alzheimers-treatment-delay-ageing\" target=\"_blank\" rel=\"noreferrer noopener\">Revolutionary New Ultrasound Procedure Could Delay Ageing and Memory Loss<\/a><br><em>BBC Science Focus \u2013 September 11, 2023<\/em><\/p>\n\n\n\n<p><a href=\"https:\/\/www.wsj.com\/health\/healthcare\/ultrasound-therapy-alzheimers-cancer-treatment-862f1390?gaa_at=eafs&amp;gaa_n=AWEtsqdNtrMM5BYJffpajgZ8buRS6rFpMuYsgvkoz5cejXGsnH64Ca63MI_mQzOTB9Y%3D&amp;gaa_ts=69cd33fa&amp;gaa_sig=kU1vuew9CkYfW4E7zLXOvZQ3-WatpwO98ede_VpyG0TrNlUfkYcyuQ5q1ykLi0hE0Kgv6zKHS8x1UgR9gTd7dA%3D%3D\">New Ultrasound Therapy Could Help Treat Alzheimer\u2019s, Cancer<\/a><br><em>The Wall Street Journal \u2013 July 31, 2023<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-key-publications\">Key Publications<\/h2>\n\n\n\n<p><em>Suggested Reading: <a aria-label=\"Focused Ultrasound: Transforming treatment of Neurodegenerative Diseases (opens in a new tab)\" class=\"ek-link\" href=\"https:\/\/fusf.sharepoint.com\/sites\/FUSF-Development\/Shared%20Documents\/Forms\/AllItems.aspx?id=%2Fsites%2FFUSF%2DDevelopment%2FShared%20Documents%2FFUS%5FNeurodegenerative%2Epdf&amp;parent=%2Fsites%2FFUSF%2DDevelopment%2FShared%20Documents&amp;p=true&amp;wdLOR=cF08C24CE%2D3E05%2D48D3%2D9B9C%2DEB0891A6E8D0&amp;ct=1661384679775&amp;or=Outlook-Body&amp;cid=0AF0D68D-F13B-4C1C-B5D7-83C9623A7D69&amp;ga=1\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Focused Ultrasound: Transforming treatment of Neurodegenerative Diseases<\/strong><\/a>. August 2022<\/em><\/p>\n\n\n\n<p><em>Suggested Reading:&nbsp;<a href=\"https:\/\/www.fusfoundation.org\/images\/pdf\/FUSF_Focused_Ultrasound_for_Alzheimers_January_2022.pdf\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"ek-link\"><strong>Focused Ultrasound for Alzheimer&#8217;s Disease<\/strong><\/a>. January 2022.&nbsp;<\/em><\/p>\n\n\n\n<p>Wang M, Zhang B, Guo R, Wang H, Wu D, Peng X, Guo H, Duan J, Yang W, Ren P, Zhang S.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41886893\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Restoration of autophagy-lysosomal function via transcranial focused ultrasound stimulation ameliorates \u03b2-amyloid pathology and cognitive deficits in an Alzheimer&#8217;s disease model<\/strong><\/a>. Ultrasonics. 2026 Mar 24;165:108075. doi: 10.1016\/j.ultras.2026.108075. PMID: 41886893<\/p>\n\n\n\n<p>Li F, Wu L, Feng X, Li Y, Fan H.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41599177\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Extracellular Vesicles in Alzheimer&#8217;s Disease: Dual Roles in Pathogenesis, Promising Avenues for Diagnosis and Therapy<\/strong><\/a>. Pharmaceutics. 2026 Jan 5;18(1):70.&nbsp;doi: 10.3390\/pharmaceutics18010070. PMID: 41599177&nbsp;<\/p>\n\n\n\n<p>\u202fLi X, Yan S, Li M, Liu R, Lu Q, Lu M, Bai F, Shen QD.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41389410\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Piezoelectric nanoparticle-driven rhythmic ultrasound neuromodulation for treatment of early-stage Alzheimer&#8217;s disease<\/strong><\/a>. Biomaterials. 2026&nbsp;May;328:123905.&nbsp;doi: 10.1016\/j.biomaterials.2025.123905.&nbsp;Epub&nbsp;2025 Dec 11. PMID: 41389410&nbsp;<\/p>\n\n\n\n<p>\u202fLee S, Kum J, Kim K, Park TY, Ko H, Na DL, Kang SY, Kim H, Kim Y, Kim J.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41424842\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Clearance of amyloid plaque via focused ultrasonication in a mouse model of Alzheimer&#8217;s disease<\/strong><\/a>.&nbsp;Theranostics. 2026 Jan 1;16(5):2310-2323.&nbsp;doi: 10.7150\/thno.122123.&nbsp;eCollection&nbsp;2026. PMID: 41424842&nbsp;<\/p>\n\n\n\n<p>Liu J, He J, Chen X, Wu D.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41123223\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Manipulation of glymphatic system by focused ultrasound: A promising treatment of neurological diseases<\/strong><\/a>. J&nbsp;Cereb&nbsp;Blood Flow&nbsp;Metab. 2025 Oct 22:271678X251383857.&nbsp;doi: 10.1177\/0271678X251383857. PMID: 41123223&nbsp;<\/p>\n\n\n\n<p>Xiao H, Sreejith A, Howson I, Cruz AA, Key T, Iliff JJ, Aryal M.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40653395\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Focused Ultrasound Enhances Glymphatic Transport Robustly Across Anesthesia Levels<\/strong><\/a>. Ultrasound Med Biol. 2025 Oct;51(10):1701-1709.&nbsp;doi: 10.1016\/j.ultrasmedbio.2025.06.009.&nbsp;Epub&nbsp;2025 Jul 12. PMID: 40653395&nbsp;<\/p>\n\n\n\n<p>Liu J, He J, Chen X, Wu D.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41123223\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Manipulation of glymphatic system by focused ultrasound: A promising treatment of neurological diseases<\/strong><\/a>. J&nbsp;Cereb&nbsp;Blood Flow&nbsp;Metab. 2025 Oct 22:271678X251383857.&nbsp;doi: 10.1177\/0271678X251383857. PMID: 41123223&nbsp;<\/p>\n\n\n\n<p>Xiao H, Sreejith A, Howson I, Cruz AA, Key T, Iliff JJ, Aryal M.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40653395\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Focused Ultrasound Enhances Glymphatic Transport Robustly Across Anesthesia Levels<\/strong><\/a>. Ultrasound Med Biol. 2025 Oct;51(10):1701-1709.&nbsp;doi: 10.1016\/j.ultrasmedbio.2025.06.009.&nbsp;Epub&nbsp;2025 Jul 12. PMID: 40653395&nbsp;<\/p>\n\n\n\n<p>Xie F, Ye Y, Hao J, Liu H, Richard SA, He S. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40801842\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Surgical advances in the treatment of Alzheimer&#8217;s disease: A comprehensive review<\/strong><\/a>. J Alzheimers Dis. 2025 Aug 13:13872877251364397. doi: 10.1177\/13872877251364397. PMID: 40801842&nbsp;<\/p>\n\n\n\n<p>Xu H, Wang G, Jiang Z, Han Y, Zhao W, Zhang H, Liu H, Liu H, Li Z, Ji F. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40376857\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Ultrasmall Nanoparticles Mitigate Tau Hyperphosphorylation to Restore Synaptic Integrity and Boost Cognitive Function in Alzheimer&#8217;s Disease<\/strong><\/a>. Adv Healthc Mater. 2025 Aug;14(20):e2500941. doi: 10.1002\/adhm.202500941. Epub 2025 May 16. PMID: 40376857&nbsp;<\/p>\n\n\n\n<p>de Koning LA, Vazquez-Matias DA, Beaino W, Vugts DJ, van Dongen GAMS, van der Flier WM, Ries M, van Vuurden DG, Vijverberg EGB, van de Giessen E. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40393907\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Drug delivery strategies to cross the blood-brain barrier in Alzheimer&#8217;s disease: a comprehensive review on three promising strategies<\/strong><\/a>. J Prev Alzheimers Dis. 2025 Aug;12(7):100204. doi: 10.1016\/j.tjpad.2025.100204. Epub 2025 May 19. PMID: 40393907&nbsp;<\/p>\n\n\n\n<p>Zheng K, Tsitsos FN, Batts AJ, Ji R, Nuriel T, Konofagou EE, Leong KW. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40665471\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Focused ultrasound-mediated APOE4 knockdown in mouse brain<\/strong><\/a>. Alzheimers Dement. 2025 Jul;21(7):e70464. doi: 10.1002\/alz.70464. PMID: 40665471&nbsp;<\/p>\n\n\n\n<p>Li W, Zha X, Zhang X, Dai H, Pu S, Yao X, Hui W, Xu R, Bao J, Yu J, Wei Y, Huang J, Guo N, Xu M, Zhao J, Cheng B, Luo Z. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40720733\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Enhanced Positron Emission Tomography Imaging of \u03b2-Amyloid through Focused Ultrasound-Mediated Gallium-68 Radiotracer Delivery across the Blood-Brain Barrier<\/strong><\/a>. ACS Chem Neurosci. 2025 Jul 28. doi: 10.1021\/acschemneuro.5c00476. PMID: 40720733&nbsp;<\/p>\n\n\n\n<p><strong><a aria-label=\" (opens in a new tab)\" class=\"ek-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Alzheimer%27s+Disease%22+AND+(%22focused+ultrasound%22+OR+HIFU)\" target=\"_blank\" rel=\"noreferrer noopener\">Click here<\/a>&nbsp;for additional references from PubMed.<\/strong><\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"sw_disease_condition_cat":[6],"sw_disease_condition_stage":[19,20],"class_list":["post-2975","sw_disease_condition","type-sw_disease_condition","status-publish","hentry","sw_disease_condition_cat-neurological"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - 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