{"id":2984,"date":"2021-12-08T20:47:00","date_gmt":"2021-12-08T20:47:00","guid":{"rendered":"https:\/\/fusfoundation.org\/?post_type=sw_disease_condition&#038;p=2984"},"modified":"2025-12-19T15:32:51","modified_gmt":"2025-12-19T19:32:51","slug":"attention-deficit-hyperactivity-disorder-adhd","status":"publish","type":"sw_disease_condition","link":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/attention-deficit-hyperactivity-disorder-adhd\/","title":{"rendered":"Attention Deficit Hyperactivity Disorder (ADHD)"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-focused-ultrasound-therapy\">Focused Ultrasound Therapy<\/h2>\n\n\n\n<p>Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with Attention Deficit Hyperactivity Disorder (ADHD). This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the brain without damaging surrounding normal tissue.<\/p>\n\n\n\n<p><strong>How it Works<\/strong><br>Where the beams converge, focused ultrasound produces neuromodulative therapeutic effects that are currently being evaluated. The mechanism of action of this treatment is being investigated, but it is still not well understood.&nbsp;<\/p>\n\n\n\n<p><strong>Advantages<br><\/strong>For certain patients, focused ultrasound could provide a noninvasive &#8211; and perhaps more effective &#8211; alternative to conventional therapy. Focused ultrasound carries less risk of complications \u2013 such as surgical wound healing or infection \u2013 at a lower cost. It can reach the desired target without damaging surrounding tissue and is repeatable, if necessary. While significant work has been accomplished, there is still much to be done before this technology will be widely available.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials\">Clinical Trials<\/h2>\n\n\n\n<p>A <a class=\"ek-link\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT05834920?term=NCT05834920&amp;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>clinical trial<\/strong><\/a> is using neuromodulation in Hong Kong to see if it can improve those who have trouble in concentration.<\/p>\n\n\n\n<p>A&nbsp;<strong><a class=\"ek-link\" href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04497363?term=04497363&amp;draw=2&amp;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\">clinical trial<\/a> <\/strong>in California is recruiting patients \u201cby invitation\u201d and is using low frequency focused ultrasound targeting the anterior cingulate in multiple treatment sessions.<\/p>\n\n\n\n<p>The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click <a href=\"https:\/\/www.clinicaltrials.gov\/search?cond=Attention-deficit%2FHyperactivity%20Disorder&amp;term=focused%20ultrasound&amp;aggFilters=status:not%20rec\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>here<\/strong><\/a>, it will take you to the latest information available from <strong><a href=\"https:\/\/www.clinicaltrials.gov\/\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.clinicaltrials.gov\/<\/a><\/strong>.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-find-a-treatment-site\">Find a Treatment Site<\/h2>\n\n\n\n<p><strong><a href=\"https:\/\/www.fusfoundation.org\/the-technology\/treatment-sites\/?indication=Attention%20Deficit%20Hyperactivity%20Disorder\" target=\"_blank\" rel=\"noreferrer noopener\">Search for a treatment center or clinical trial near you.<\/a><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-regulatory-approval-and-reimbursement\">Regulatory Approval and Reimbursement<\/h2>\n\n\n\n<p>Focused ultrasound treatment for ADHD is not yet approved by regulatory bodies or covered by medical insurance companies.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-notable-papers\">Notable Papers<\/h2>\n\n\n\n<p>Polte S,\u00a0Klingmann\u00a0L,\u00a0Se\u00dfmann\u00a0A, Schwichtenberg S, Herrmann CS, Witt K,\u00a0Roheger\u00a0M. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41295447\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Neuromodulatory\u00a0Effects of Transcranial Pulse Stimulation (TPS) in Neurological and Psychiatric Disorders-A Systematic Review and Meta-Analysis<\/strong><\/a>. Neurol Int. 2025 Nov 18;17(11):188.\u00a0doi: 10.3390\/neurolint17110188. PMID: 41295447\u00a0<\/p>\n\n\n\n<p>Wang M, Xie Z, Wang T, Dong S, Ma Z, Zhang X, Li X, Yuan Y. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39244077\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Low-intensity transcranial ultrasound stimulation improves memory behavior in an ADHD rat model by modulating cortical functional network connectivity<\/strong><\/a>. Neuroimage. 2024 Oct 1;299:120841. doi: 10.1016\/j.neuroimage.2024.120841. Epub 2024 Sep 6. PMID: 39244077.&nbsp;<\/p>\n\n\n\n<p>Lord B, Sanguinetti JL, Ruiz L, Miskovic V, Segre J, Young S, Fini ME, Allen JJB. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38895168\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Transcranial focused ultrasound to the posterior cingulate cortex modulates default mode network and subjective experience: an fMRI pilot study<\/strong><\/a>. Front Hum Neurosci. 2024 Jun 4;18:1392199. doi: 10.3389\/fnhum.2024.1392199. PMID: 38895168; PMCID: PMC11184145.&nbsp;<\/p>\n\n\n\n<p>Hu YY, Yang G, Liang XS, Ding XS, Xu DE, Li Z, Ma QH, Chen R, Sun YY. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10030814\/%22%20\/l%20%22:~:text=High%2Dintensity%20ultrasound%20has%20therapeutic,less%20damage%20to%20the%20tissue\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application<\/strong><\/a>. Front Neurol. 2023 Mar 8;14:1117188. doi: 10.3389\/fneur.2023.1117188. PMID: 36970512; PMCID: PMC10030814.&nbsp;<\/p>\n\n\n\n<p>Materna L, Wiesner CD, Shushakova A, Trieloff J, Weber N, Engell A, Schubotz RI, Bauer J, Pedersen A, Ohrmann P.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31025560\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Adult patients with ADHD differ from healthy controls in implicit, but not explicit, emotion regulation<\/strong><\/a>. J Psychiatry Neurosci. 2019 Sep 1;44(5):340-349. doi: 10.1503\/jpn.180139.<\/p>\n\n\n\n<p>Tang C, Wei Y, Zhao J, Nie J.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30153660\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Different Developmental Pattern of Brain Activities in ADHD: A Study of Resting-State fMRI<\/strong><\/a>. Dev Neurosci. 2018;40(3):246-257. doi: 10.1159\/000490289. Epub 2018 Jul 13.<\/p>\n\n\n\n<p><strong><a class=\"ek-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28%22focused+ultrasound%22+OR+HIFU%29+and+%22attention%22+and+%22activity%22&amp;sort=date\" target=\"_blank\" rel=\"noreferrer noopener\">Click here<\/a>&nbsp;for additional references from PubMed.<\/strong><\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"sw_disease_condition_cat":[6,259],"sw_disease_condition_stage":[20],"class_list":["post-2984","sw_disease_condition","type-sw_disease_condition","status-publish","hentry","sw_disease_condition_cat-neurological","sw_disease_condition_cat-psychiatric"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - 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