{"id":3038,"date":"2021-12-08T13:45:00","date_gmt":"2021-12-08T17:45:00","guid":{"rendered":"https:\/\/fusfoundation.org\/?post_type=sw_disease_condition&#038;p=3038"},"modified":"2026-05-13T18:36:56","modified_gmt":"2026-05-13T22:36:56","slug":"obsessive-compulsive-disorder-ocd","status":"publish","type":"sw_disease_condition","link":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/obsessive-compulsive-disorder-ocd\/","title":{"rendered":"Obsessive-Compulsive Disorder (OCD)\u00a0"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-focused-ultrasound-therapy\">Focused Ultrasound Therapy<\/h2>\n\n\n\n<p>Focused ultrasound is a noninvasive therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with obsessive compulsive disorder (OCD). This novel technology focuses beams of ultrasonic energy precisely and accurately on targets deep in the brain without damaging surrounding normal tissue.<\/p>\n\n\n\n<p><strong>How it Works<\/strong><br>Where the beams converge, focused ultrasound produces precise ablation (thermal destruction of tissue) of the desired target which treats OCD without incisions or radiation.<\/p>\n\n\n\n<p><strong>Advantages<\/strong><br>Current treatments for OCD include medications, surgery (radiofrequency or laser ablation, deep brain stimulation), or stereotactic radiosurgery (gamma knife, linear accelerator), all of which have limitations and side effects.<\/p>\n\n\n\n<p>Focused ultrasound has the potential to provide an alternative to invasive surgery or radiosurgery via precise thermal ablation, or to augment drug therapy.&nbsp; It is noninvasive and has reduced risk for infection and blood clots. Focused ultrasound can also offer precise targeting to minimize damage to non-targeted healthy brain.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials\">Clinical Trials<\/h2>\n\n\n\n<p>A <strong><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05467085?term=focused+ultrasound&amp;recrs=a&amp;cond=Obsessive-Compulsive+Disorder&amp;draw=2&amp;rank=1\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"ek-link\">clinical trial<\/a><\/strong> using low intensity focused ultrasound is recruiting patients with OCD.<\/p>\n\n\n\n<p>A <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06816511?term=NCT06816511&amp;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\"><strong><\/strong><strong>clinical trial<\/strong><\/a> in Taiwan is recruiting patients with OCD by invitation only for treatment with the Insightec device.&nbsp;<\/p>\n\n\n\n<p>The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click <a href=\"https:\/\/clinicaltrials.gov\/search?cond=Obsessive-Compulsive%20Disorder&amp;term=focused%20ultrasound&amp;aggFilters=status:not%20rec\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>here<\/strong><\/a>, it will take you to the latest information available from <a href=\"https:\/\/www.clinicaltrials.gov\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/www.clinicaltrials.gov\/<\/strong><\/a>.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-find-a-treatment-site\">Find a Treatment Site<\/h2>\n\n\n\n<p><strong><a href=\"https:\/\/www.fusfoundation.org\/the-technology\/treatment-sites\/?indication=Obsessive%20Compulsive%20Disorder%20%28OCD%29\" target=\"_blank\" rel=\"noreferrer noopener\">Search for a treatment center or clinical trial near you.<\/a><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-regulatory-approval-and-reimbursement\">Regulatory Approval and Reimbursement<\/h2>\n\n\n\n<p>Focused ultrasound is not approved by any regulatory bodies worldwide as a treatment for OCD, nor is the treatment reimbursed by medical insurance providers.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-additional-resources\">Additional Resources<\/h2>\n\n\n\n<figure class=\"wp-block-embed alignright is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Dr. Jin Woo Chang Discusses Focused Ultrasound Study for Obsessive-Compulsive Disorder (OCD)\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/C8bcz0luFO0?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nimh.nih.gov\/health\/topics\/obsessive-compulsive-disorder-ocd\/index.shtml\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>National Institute of Mental Health<\/strong><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/iocdf.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>International OCD Foundation<\/strong><\/a><\/li>\n\n\n\n<li><a href=\"http:\/\/onemind.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>One Mind<\/strong><\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-notable-papers\">Notable Papers<\/h2>\n\n\n\n<p>Arulpragasam\u00a0AR,\u00a0Theyel\u00a0B, Barredo J, Pouille F, Gillotti JG, Greenberg BD, Wout-Frank MV&#8217;, Philip NS.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41796716\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Low Intensity Focused Ultrasound Neuromodulation in Psychiatric Disorders: Mechanisms, Models, and Missing Links<\/strong><\/a>. Biol Psychiatry. 2026 Mar\u00a06:S0006-3223(26)00097-1.\u00a0doi: 10.1016\/j.biopsych.2026.02.019. PMID: 41796716\u00a0<\/p>\n\n\n\n<p>Davidson B, Clappison A, Mithani K, Favi Bocca L, Giacobbe P, Nestor S, Meng Y,\u00a0Ottoy\u00a0J, Rabin JS, Burke M,\u00a0Uludag\u00a0K, Hamani C, Lipsman N,\u00a0Goubran\u00a0M.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41672276\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Microstructural, morphological, and metabolic changes following magnetic resonance guided focused ultrasound capsulotomy<\/strong><\/a>. Biol Psychiatry\u00a0Cogn\u00a0Neurosci\u00a0Neuroimaging. 2026 Feb\u00a09:S2451-9022(26)00029-7.\u00a0doi: 10.1016\/j.bpsc.2026.01.011. PMID: 41672276\u00a0<\/p>\n\n\n\n<p>Prasad D, Jain R, Samal B, Sriram N,\u00a0Drysch\u00a0A, Menon SS, Selner AN, Mossner JM, Rosenow JM.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41711827\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Focused ultrasound neuromodulation for psychiatric disorders: a scoping review of clinical applications and current progress<\/strong><\/a>. J Neural Transm (Vienna). 2026 Feb 19.\u00a0doi: 10.1007\/s00702-026-03113-3. PMID: 41711827\u00a0<\/p>\n\n\n\n<p>Arulpragasam&nbsp;AR, Philip NS.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40764758\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Quiet waves, deep impact: acoustic modeling of low-intensity focused ultrasound<\/strong><\/a>. Neuropsychopharmacology. 2026 Jan;51(1):351-353.&nbsp;doi: 10.1038\/s41386-025-02191-3. PMID: 40764758&nbsp;<\/p>\n\n\n\n<p>Wang F, Ye K,&nbsp;Paerhati&nbsp;H, Suo J, Shen Z, Zhang J, Li D, Zhan S, Lai Y, Sun B.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41207452\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Imaging characteristics correlated with outcomes of cranial&nbsp;MRgFUS&nbsp;&#8211; a systematic review<\/strong><\/a>. Neuroimage. 2025 Nov&nbsp;7;323:121571.&nbsp;doi: 10.1016\/j.neuroimage.2025.121571. PMID: 41207452&nbsp;<\/p>\n\n\n\n<p>De Schlichting E, Huang Y, Jones RM, Meng Y, Cao X, Baskaran A, Hynynen K, Hamani C, Lipsman N,&nbsp;Goubran&nbsp;M, Davidson B. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41072044\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Focused ultrasound capsulotomy: predicting the probability of successful lesioning based on skull morphology<\/strong><\/a>. J&nbsp;Neurosurg. 2025 Oct 10:1-10.&nbsp;doi: 10.3171\/2025.6.JNS2588. PMID: 41072044&nbsp;<\/p>\n\n\n\n<p>Michalopoulou PG, Meshreky KM,&nbsp;Hommerich&nbsp;Z, Shergill SS.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40999798\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Neuromodulation and neural networks in psychiatric disorders:&nbsp;current status&nbsp;and emerging prospects<\/strong><\/a>. Psychol Med. 2025 Sep 26;55:e281.&nbsp;doi: 10.1017\/S003329172510158X. PMID: 40999798&nbsp;<\/p>\n\n\n\n<p>Martin E, Roberts M, Grigoras IF, Wright O, Nandi T, Rieger SW, Campbell J, den Boer T, Cox BT, Stagg CJ, Treeby BE. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40913042\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Ultrasound\u202fsystem\u202ffor\u202fprecise\u202fneuromodulation\u202fof\u202fhuman\u202fdeep\u202fbrain\u202fcircuits<\/strong><\/a>. Nat Commun. 2025 Sep 5;16(1):8024. doi: 10.1038\/s41467-025-63020-1. PMID:\u202f40913042\u202f&nbsp;<\/p>\n\n\n\n<p>Davidson B, Xhima K, Cosgrove R, Hamani C, Eitan R, Rezai A, LeBlang S, Philip NS, Lipsman N. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40854478\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>A roadmap for focused ultrasound applications in psychiatry: Proceedings of the 2024 Symposium on Focused Ultrasound in Psychiatry (FUS-PULSE)<\/strong><\/a>. Brain Stimul. 2025 Aug 23:S1935-861X(25)00305-5. doi: 10.1016\/j.brs.2025.08.012. PMID: 40846278&nbsp;<\/p>\n\n\n\n<p>Darmani G, Ramezanpour H, Sarica C, Annirood R, Grippe T, Nankoo JF, Fomenko A, Santyr B, Zeng K, Vetkas A, Samuel N, Davidson B, Fasano A, Lankarany M, Kalia SK, Pichardo S, Lozano AM, Chen R. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40108143\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Individualized\u202fnon-invasive\u202fdeep\u202fbrain\u202fstimulation\u202fof the\u202fbasal\u202fganglia\u202fusing\u202ftranscranial\u202fultrasound\u202fstimulation<\/strong><\/a>. Nat Commun. 2025 Mar 19;16(1):2693. doi: 10.1038\/s41467-025-57883-7.PMID:\u202f40108143\u202f&nbsp;<\/p>\n\n\n\n<p>Riva-Posse P, Figee M. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40086896\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>A Safe Step in the Right Direction: Focused Ultrasound in Obsessive-Compulsive Disorder and Depression<\/strong><\/a>. Biol Psychiatry. 2025 Apr 1;97(7):664-665. doi: 10.1016\/j.biopsych.2025.01.024. PMID: 40086896&nbsp;<\/p>\n\n\n\n<p>de Souza DN, Seas A, Blethen K, Feigal J, Shah BR, Grant GA, Harward SC. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39936841\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Focused ultrasound as an emerging therapy for neuropsychiatric disease: Historical perspectives and a review of current clinical data<\/strong><\/a>. Psychiatry Clin Neurosci. 2025 Feb 12. doi: 10.1111\/pcn.13799. PMID: 39936841&nbsp;<\/p>\n\n\n\n<p>Chou T, Kochanowski BJ, Hayden A, Borron BM, Barbeiro MC, Xu J, Kim JW, Zhang X, Bouchard RR, Phan KL, Goodman WK, Dougherty DD. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38691076\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>A Low-Intensity Transcranial Focused Ultrasound Parameter Exploration Study of the Ventral Capsule\/Ventral Striatum<\/strong><\/a>. Neuromodulation. 2025 Jan;28(1):146-154. doi: 10.1016\/j.neurom.2024.03.004. Epub 2024 Apr 29. PMID: 38691076&nbsp;<\/p>\n\n\n\n<p>Chang KW, Chang JG, Jung HH, Kim CH, Chang JW, Kim SJ. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39468190\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Long-term clinical outcome of a novel bilateral capsulotomy with focused ultrasound in refractory obsessive-compulsive disorder treatment<\/strong><\/a>. Mol Psychiatry. 2024 Oct 28. doi: 10.1038\/s41380-024-02799-9. PMID: 39468190&nbsp;<\/p>\n\n\n\n<p>Hamani C, Davidson B, Rabin JS, Goubran M, Boone L, Hynynen K, De Schlichting E, Meng Y, Huang Y, Jones RM, Baskaran A, Marawi T, Richter MA, Levitt A, Nestor SM, Giacobbe P, Lipsman N. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39187171\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Long-term safety and efficacy of focused ultrasound capsulotomy for obsessive-compulsive disorder and major depressive disorder<\/strong><\/a>. Biol Psychiatry. 2024 Aug 24:S0006-3223(24)01548-8. doi: 10.1016\/j.biopsych.2024.08.015. PMID: 39187171&nbsp;<\/p>\n\n\n\n<p>Henn MC, Smith HD, Lopez Ramos CG, Shafie B, Abaricia J, Stevens I, Rockhill AP, Cleary DR, Raslan AM. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39217636\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>A systematic review of focused ultrasound for psychiatric disorders: current applications, opportunities, and challenges<\/strong><\/a>. Neurosurg Focus. 2024 Sep 1;57(3):E8. doi: 10.3171\/2024.6.FOCUS24278. PMID: 39217636&nbsp;<\/p>\n\n\n\n<p>Hurwitz TA, Avecillas-Chasin JM, Bogod NM, Honey CR. <a class=\"ek-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38272366\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Ventral targeted anterior capsulotomy for treatment-resistant depression and obsessive-compulsive disorder: A treatment method with cases<\/strong><\/a>. J Affect Disord. 2024 Jan 23;350:887-894. doi: 10.1016\/j.jad.2024.01.176. PMID: 38272366&nbsp;<\/p>\n\n\n\n<p>Guinjoan SM. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36969502\/\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"ek-link\"><strong>Personalized Definition of Surgical Targets in Major Depression and Obsessive-Compulsive Disorder: A Potential Role for Low-Intensity Focused Ultrasound?<\/strong><\/a> Pers Med Psychiatry. 2023;37-38:100100. doi: 10.1016\/j.pmip.2023.100100. Epub 2023 Feb 27. <\/p>\n\n\n\n<p>Chang JG, Kim DW, Jung HH, Chang WS, Kim CH, Kim SJ, Chang JW.<strong> <a aria-label=\" (opens in a new tab)\" class=\"ek-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36706511\/\" target=\"_blank\" rel=\"noreferrer noopener\">Evaluation of changes in neural oscillation after bilateral capsulotomy in treatment refractory obsessive-compulsive disorder using magnetoencephalogram<\/a><\/strong>. Asian J Psychiatr. 2023 Jan 20;82:103473. doi: 10.1016\/j.ajp.2023.103473.<\/p>\n\n\n\n<p>Mustroph ML, Cosgrove GR, Williams ZM. <strong><a aria-label=\" (opens in a new tab)\" class=\"ek-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35464603\/\" target=\"_blank\" rel=\"noreferrer noopener\">The Evolution of Modern Ablative Surgery for the Treatment of Obsessive-Compulsive and Major Depression Disorders<\/a><\/strong>. Front Integr Neurosci. 2022 Apr 6;16:797533. doi: 10.3389\/fnint.2022.797533. eCollection 2022.<\/p>\n\n\n\n<p><strong><a aria-label=\"Click here (opens in a new tab)\" class=\"ek-link\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28%22focused+ultrasound%22+OR+HIFU%29+and+%22obsessive+compulsive+disorder%22&amp;sort=date\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Click <\/strong>here<\/a>&nbsp;for additional references from PubMed.<\/strong><\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"sw_disease_condition_cat":[6,259],"sw_disease_condition_stage":[20],"class_list":["post-3038","sw_disease_condition","type-sw_disease_condition","status-publish","hentry","sw_disease_condition_cat-neurological","sw_disease_condition_cat-psychiatric"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - 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