{"id":3207,"date":"2021-12-08T14:17:00","date_gmt":"2021-12-08T14:17:00","guid":{"rendered":"https:\/\/fusfoundation.org\/?post_type=sw_disease_condition&p=3207"},"modified":"2026-05-13T18:15:36","modified_gmt":"2026-05-13T22:15:36","slug":"ectopic-pregnancy","status":"publish","type":"sw_disease_condition","link":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/ectopic-pregnancy\/","title":{"rendered":"Ectopic Pregnancy"},"content":{"rendered":"\n

Focused Ultrasound Therapy<\/h2>\n\n\n\n

Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with ectopic pregnancy. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue.<\/p>\n\n\n\n

How it Works<\/strong>
Where the beams converge, focused ultrasound produces precise ablation (thermal destruction of tissue) enabling the ectopic pregnancy to be treated without surgery. While some treatments of ectopic pregnancy have been reported, further research is needed before this can become routinely available.<\/p>\n\n\n\n

Advantages<\/strong>
The primary options for treatment of ectopic pregnancy will sometimes require surgery.<\/p>\n\n\n\n

For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications \u2013 such as surgical wound healing or infection \u2013 at a lower cost. It can reach the desired target without damaging surrounding tissue and is repeatable, if necessary.<\/p>\n\n\n\n

Clinical Trials<\/h2>\n\n\n\n

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of ectopic pregnancy.<\/p>\n\n\n\n

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here<\/strong><\/a>, it will take you to the latest information available from https:\/\/www.clinicaltrials.gov\/<\/strong><\/a>. <\/p>\n\n\n\n

Find a Treatment Site<\/h2>\n\n\n\n

Search for a treatment center or clinical trial near you.<\/a><\/strong><\/p>\n\n\n\n

Regulatory Approval and Reimbursement<\/h2>\n\n\n\n

Focused ultrasound treatment for ectopic pregnancy is not yet approved by regulatory bodies or covered by medical insurance companies.<\/p>\n\n\n\n

Notable Papers<\/h2>\n\n\n\n

Li L, Zhang G, Sun M, Lang J, Yu X.\u00a0Application of high-intensity focused ultrasound in\u00a0gynaecological\u00a0diseases<\/strong><\/a>. Int J Hyperthermia. 2026 Dec;43(1):2635294.\u00a0doi: 10.1080\/02656736.2026.2635294.\u00a0Epub\u00a02026 Mar 23. PMID: 41867046\u00a0<\/p>\n\n\n\n

Bucak\u00a0M,\u00a0Akkus\u00a0F, Turan S, Turan O.\u00a0Cesarean scar pregnancy as a precursor lesion for placenta accreta spectrum: evidence and implications<\/strong><\/a>. J Matern Fetal Neonatal Med. 2026 Dec;39(1):2640651.\u00a0doi: 10.1080\/14767058.2026.2640651.\u00a0Epub\u00a02026 Mar 12. PMID: 41819987\u00a0<\/p>\n\n\n\n

Peng Y, Dai Y, Wen C, Yu G, Jin P.\u00a0Clinical efficacy and safety of cervical pregnancy treated with high-intensity focused ultrasound versus uterine artery embolization prior to ultrasound-guided suction curettage: a retrospective study<\/strong><\/a>. Int J Hyperthermia. 2026 Dec;43(1):2616375.\u00a0doi: 10.1080\/02656736.2026.2616375.\u00a0Epub\u00a02026 Feb 3. PMID: 41634949\u00a0<\/p>\n\n\n\n

Long Y, Peng Y, Yuan Z, Wen C, Dai Y, Xia H, Liu X, Liu M, Zhang L, Jing P. Individualized risk-stratified management after HIFU treatment for placenta increta: a fertility preservation strategy<\/strong><\/a>. Int J Hyperthermia. 2026 Dec;43(1):2643511.\u00a0doi: 10.1080\/02656736.2026.2643511.\u00a0Epub\u00a02026 Mar 23. PMID: 41873037\u00a0<\/p>\n\n\n\n

Wu ZW, Lin CB, Lin YY, Cai YJ, Xie L. Textbook outcomes in patients with a cesarean scar pregnancy: A comprehensive analysis from a single Eastern center in China<\/strong><\/a>. Medicine (Baltimore). 2025 Oct 10;104(41):e45140. doi: 10.1097\/MD.0000000000045140. PMID: 41088575 <\/p>\n\n\n\n

Yin N, Wei F, Gao Z, Yang Z, Zhou X. Comparison of curettage with and without high intensity focused ultrasound in the management of caesarean scar pregnancy<\/strong><\/a>. Curr Probl Surg. 2025 Nov;72:101884. doi: 10.1016\/j.cpsurg.2025.101884. Epub 2025 Aug 22. PMID: 41162105 <\/p>\n\n\n\n

Zhu X, Sun X, Ye M, Xue M. The clinical study of high-intensity focused ultrasound for the treatment of 160 cases of postpartum placenta increta<\/strong><\/a>. Int J Hyperthermia. 2025 Dec;42(1):2473386. doi: 10.1080\/02656736.2025.2473386. Epub 2025 Mar 5. PMID: 40044129 <\/p>\n\n\n\n

Yang J, Luo X, Guo L, Cheng H, Tang Y, Song Y, Li W, Xiong L, Gao F, Cheng W, Zhu Q. A novel scoring model to predict massive hemorrhage during dilatation and curettage following focused ultrasound ablation surgery in patients with type 2 cesarean scar pregnancy<\/strong><\/a>. Int J Hyperthermia. 2025 Dec;42(1):2495362. doi: 10.1080\/02656736.2025.2495362. Epub 2025 Apr 29. PMID: 40296674 <\/p>\n\n\n\n

Sang C, Shi Q, Zhao L, Kang Y, Zhao S, Wang Z. Reducing intraoperative hemorrhage in type II caesarean scar pregnancy: a study protocol comparing high-intensity focused ultrasound (HIFU) pretreatment vs. hysteroscopy-guided suction curettage-an open-label, 1:1 parallel-group, superiority-design investigator-initiated trial (IIT)<\/strong><\/a>. Trials. 2025 Aug 6;26(1):275. doi: 10.1186\/s13063-025-08967-8. PMID: 40770352 <\/p>\n\n\n\n

Fu Y, Lei Z, Gong L, Wang X. New prospects for high-intensity focused ultrasound ablation in the treatment of uterine arteriovenous fistula associated with retained products of conception: A retrospective cohort study<\/strong><\/a>. Medicine (Baltimore). 2025 Jul 4;104(27):e43211. doi: 10.1097\/MD.0000000000043211. PMID: 40629617 <\/p>\n\n\n\n

Huang JR, Sun LY, Tang Y, Wen MB, Yang MT, Xu F, Shi Q, Hu HQ. Cesarean section diverticulum area predicting the intraoperative hemorrhage at suction curettage for cesarean scar pregnancy after focused ultrasound ablation surgery<\/strong><\/a>. Int J Hyperthermia. 2025 Dec;42(1):2468757. doi: 10.1080\/02656736.2025.2468757. Epub 2025 Feb 25. PMID: 40000009 <\/p>\n\n\n\n

Alameddine S, Lucidi A, Jurkovic D, Timor Tritsch I, Coutinho CM, Ranucci L, Buca D, Khalil A, Jauniaux E, Mappa I, D’Antonio F. Treatments for cesarean scar pregnancy: a systematic review and meta-analysis<\/strong><\/a>. J Matern Fetal Neonatal Med. 2024 Dec;37(1):2327569. doi: 10.1080\/14767058.2024.2327569. Epub 2024 Oct 9. PMID: 39385517 <\/p>\n\n\n\n

Alameddine S, Lucidi A, Jurkovic D, Timor Tritsch I, Coutinho CM, Ranucci L, Buca D, Khalil A, Jauniaux E, Mappa I, D’Antonio F. Treatments for cesarean scar pregnancy: a systematic review and meta-analysis<\/strong><\/a>. J Matern Fetal Neonatal Med. 2024 Dec;37(1):2327569. doi: 10.1080\/14767058.2024.2327569. Epub 2024 Oct 9. PMID: 39385517 <\/p>\n\n\n\n

Xu L, Chen H, Xiao Y, Jiang Z, Zhang J, Jiang Y, Ling D. High-intensity focused ultrasound ablation combined with hysteroscopy for the treatment of uterine arteriovenous fistula associated with retained products of conception: a prospective cohort study<\/strong><\/a>. J Minim Invasive Gynecol. 2024 Sep 12:S1553-4650(24)00414-X. doi: 10.1016\/j.jmig.2024.09.010. PMID: 39277102 <\/p>\n\n\n\n

Wang Z, Chang Y, Li S. Efficacy and Safety of High-intensity Focused Ultrasound Compared with Uterine Artery Embolization in Cesarean Section Pregnancy: A Meta-analysis<\/strong><\/a>. J Minim Invasive Gynecol. 2023 Nov;30(11):931-932. doi: 10.1016\/j.jmig.2023.07.014. Epub 2023 Aug 14. PMID: 37586477 <\/p>\n\n\n\n

Li H, Tan H. Regarding “Efficacy and Safety of High-intensity Focused Ultrasound Compared with Uterine Artery Embolization in Cesarean Section Pregnancy: A Meta-analysis”<\/strong><\/a>. J Minim Invasive Gynecol. 2023 Nov;30(11):931. doi: 10.1016\/j.jmig.2023.07.016. Epub 2023 Aug 27. PMID: 37643660 <\/p>\n\n\n\n

Mu L, Weng H, Dong Y. <\/strong>Analysis of risk factors for patients with cesarean scar pregnancy treated with methotrexate combined with suction curettage<\/strong><\/a>.<\/strong> Arch Gynecol Obstet. 2023 Sep;308(3):913-918. doi: 10.1007\/s00404-023-07049-x. Epub 2023 May 2. PMID: 37131042 <\/p>\n\n\n\n

Mu L, Weng H, Dong Y. Analysis of risk factors for patients with cesarean scar pregnancy treated with methotrexate combined with suction curettage<\/a>.<\/strong> Arch Gynecol Obstet. 2023 Sep;308(3):913-918. doi: 10.1007\/s00404-023-07049-x. Epub 2023 May 2. PMID: 37131042<\/p>\n\n\n\n

Liu Y, Wang L, Zhu X. <\/strong>Efficacy and Safety of High-intensity Focused Ultrasound Compared with Uterine Artery Embolization in Cesarean Section Pregnancy: A Meta-analysis<\/strong><\/a>. J Minim Invasive Gynecol. 2023 Jun;30(6):446-454. doi: 10.1016\/j.jmig.2023.02.021. Epub 2023 Mar 7. PMID: 36893898 <\/p>\n\n\n\n

Li Y, Hua C. Is High-intensity Focused Ultrasound Superior to Uterine Artery Embolization in Cesarean Scar Pregnancy and Subsequent Pregnancy Outcomes? A Meta-analysis of the Chinese Population<\/strong><\/a>. J Minim Invasive Gynecol. 2023 Mar;30(3):180-191. doi: 10.1016\/j.jmig.2022.11.015. Epub 2022 Nov 26.<\/p>\n\n\n\n

Mm YL, Bm LW, Postdoc XZ. Efficacy and safety of high-intensity focused ultrasound compared with uterine artery embolization in caesarean section pregnancy: A meta-analysis<\/strong><\/a>. J Minim Invasive Gynecol. 2023 Mar 7:S1553-4650(23)00076-6. doi: 10.1016\/j.jmig.2023.02.021.<\/p>\n\n\n\n

Peng Y, Dai Y, Yu G, Jin P. High-intensity focused ultrasound ablation combined with systemic methotrexate treatment of intramural ectopic pregnancy: A case report<\/a><\/strong>. Medicine (Baltimore). 2022 Nov 18;101(46):e31615. doi: 10.1097\/MD.0000000000031615.<\/p>\n\n\n\n

Wang W, Chen Y, Yang Y, Qu D, Jiang J. High-intensity focused ultrasound compared with uterine artery chemoembolization with methotrexate for the management of cesarean scar pregnancy<\/a>.<\/strong> Int J Gynaecol Obstet. 2022 Sep;158(3):572-578. doi: 10.1002\/ijgo.14036. Epub 2021 Dec 5. <\/p>\n\n\n\n

Chen H, Tan X, Xiong W, Wang X. High-intensity focused ultrasound for uterine arteriovenous malformation associated with retained products of conception: A case report<\/a>.<\/strong> Asian J Surg. 2022 Jul 22:S1015-9584(22)00971-X. doi: 10.1016\/j.asjsur.2022.07.026.<\/p>\n\n\n\n

Liu Y, Yin Q, Xu F, Luo S. Clinical efficacy and safety of high-intensity focused ultrasound (HIFU) ablation in treatment of cesarean scar pregnancy (CSP) I and II<\/a>.<\/strong> BMC Pregnancy Childbirth. 2022 Jul 30;22(1):607. doi: 10.1186\/s12884-022-04848-z. <\/p>\n\n\n\n

Guan X, Huang X, Ye M, Huang G, Xiao X, Chen J. Treatment of Placenta Increta With High-Intensity Focused Ultrasound Ablation and Leaving the Placenta in situ: A Multicenter Comparative Study<\/a><\/strong>. Front Med (Lausanne). 2022 Apr 7;9:871528. doi: 10.3389\/fmed.2022.871528. eCollection 2022.<\/p>\n\n\n\n

Zhu XG, Shi QL, Deng XL, Xu W, Xue M. Clinical effect and influencing factors of focused ultrasound ablation surgery combined with suction curettage for the treatment of mass-type cesarean scar pregnancy<\/a>.<\/strong> Zhonghua Fu Chan Ke Za Zhi. 2022 Apr 25;57(4):253-258. doi: 10.3760\/cma.j.cn112141-20210902-00483.<\/p>\n\n\n\n

Diakosavvas M, Kathopoulis N, Angelou K, Chatzipapas I, Zacharakis D, Kypriotis K, Grigoriadis T, Protopapas A. Hysteroscopic treatment of Cesarean Scar Pregnancy: A systematic review<\/strong><\/a>. Eur J Obstet Gynecol Reprod Biol. 2022 Mar;270:42-49. doi: 10.1016\/j.ejogrb.2021.12.038. Epub 2022 Jan 5.<\/p>\n\n\n\n

Mu L, Weng H, Wang X. Evaluation of the treatment of high intensity focused ultrasound combined with suction curettage for exogenous cesarean scar pregnancy<\/strong><\/a>. Arch Gynecol Obstet. 2022 Mar 18. doi: 10.1007\/s00404-022-06487-3.<\/p>\n\n\n\n

Yin Y, Pan F, He M, Zhang C, Liu Y. High intensity focused ultrasound combined with ultrasound-guided suction curettage treatment for cesarean scar pregnancy: a comparison of different HIFU sonication strategies<\/strong><\/a>. Int J Hyperthermia. 2022;39(1):390-396. doi: 10.1080\/02656736.2022.2044078.<\/p>\n\n\n\n

Legris ML, Gabriele V, Host A, Akladios C, Garbin O, Lecointre L. Cesarean scar pregnancy: Two case report and therapeutic management algorithm<\/strong><\/a>. J Gynecol Obstet Hum Reprod. 2021 Apr;50(4):102056. doi: 10.1016\/j.jogoh.2020.102056. Epub 2021 Jan 2.<\/p>\n\n\n\n

Mi W, Pei P, Zheng Y. Clinical efficacy and safety between high-intensity focused ultrasound and uterine artery embolization for cesarean scar pregnancy: a systematic review and a meta-analysis<\/strong><\/a>. Ann Palliat Med. 2021 Jun;10(6):6379-6387. doi: 10.21037\/apm-21-839.<\/p>\n\n\n\n

Liu CN, Tang L, Sun Y, Liu YH, Yu HJ. Clinical outcome of high-intensity focused ultrasound as the preoperative management of cesarean scar pregnancy<\/a><\/strong>. Taiwan J Obstet Gynecol. 2020 May;59(3):387-391. doi: 10.1016\/j.tjog.2020.03.009.

Huo X, Xie Y, Yang L, Deng K, Liu Y. Doppler Ultrasound Evaluation of the Efficacy of High Intensity Focused Ultrasound in Treatment of Cesarean Section Scar Pregnancy<\/a><\/strong>. J Coll Physicians Surg Pak. 2020 Mar;30(3):240-244. doi: 10.29271\/jcpsp.2020.03.240.

Qian H, Tian G, Zheng H, Liang W, Jiang T. Successful management of diaphragmatic ectopic pregnancy using ultrasound-guided percutaneous microwave ablation<\/a><\/strong>. J Obstet Gynaecol Res. 2020 Jan;46(1):181-185. doi: 10.1111\/jog.14131. Epub 2019 Oct 22.<\/p>\n\n\n\n

Jiang J, Xue M. The treatment of cervical pregnancy with high-intensity focused ultrasound followed by suction curettage: report of three cases<\/strong><\/a>. Int J Hyperthermia. 2019 Jan 24:1-4. doi: 10.1080\/02656736.2018.1563914.<\/p>\n\n\n\n

Yu L, Xu L, Xu X. Treatment of cornual pregnancy in a patient with adenomyosis by high-intensity focused ultrasound (HIFU) ablation: A case report<\/strong><\/a>. Medicine (Baltimore). 2017 Dec;96(48):e8874. doi: 10.1097\/MD.0000000000008874.<\/p>\n\n\n\n

He GB1, Luo W, Zhou XD, Liu LW, Yu M, Ma XD. A preliminary clinical study on high-intensity focused ultrasound therapy for tubal pregnancy<\/a><\/strong>. Scott Med J. 2011 Nov;56(4):214-9.<\/p>\n\n\n\n

Click here<\/a> for additional references from PubMed.<\/strong><\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":false,"_editorskit_reading_time":3,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"sw_disease_condition_cat":[28],"sw_disease_condition_stage":[20],"class_list":["post-3207","sw_disease_condition","type-sw_disease_condition","status-publish","hentry","sw_disease_condition_cat-womens-health"],"acf":[],"yoast_head":"\nEctopic Pregnancy - Focused Ultrasound Foundation<\/title>\n<meta name=\"description\" content=\"Learn about clinical trials that are investigating the use of focused ultrasound to treat Ectopic Pregnancy\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/ectopic-pregnancy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ectopic Pregnancy - 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