{"id":3285,"date":"2019-05-03T14:26:00","date_gmt":"2019-05-03T14:26:00","guid":{"rendered":"https:\/\/fusfoundation.org\/?post_type=sw_disease_condition&p=3285"},"modified":"2025-05-30T17:09:11","modified_gmt":"2025-05-30T21:09:11","slug":"chronic-wounds","status":"publish","type":"sw_disease_condition","link":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/chronic-wounds\/","title":{"rendered":"Chronic Wounds"},"content":{"rendered":"\n

Focused Ultrasound Therapy<\/h2>\n\n\n\n

Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with wounds. This novel technology focuses beams of ultrasonic energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue.<\/p>\n\n\n\n

How it Works<\/strong>
Where the beams converge, focused ultrasound produces hyperthermia, which can improve the penetration of antimicrobial agents and promote a more rapid healing of the wound. Another mechanism of action is to use a device designed to treat close to the skin which has very specific healing patterns that have been established and characterized. See this link<\/strong><\/a> for more details. <\/p>\n\n\n\n

Advantages<\/strong>
The primary options for treatment of wounds are debridement, medications and time, but for delayed or refractory wounds, surgery, vascular grafting and even amputations have been required if wound healing does not occur. It is also helpful to be able to predict the healing patterns that are likely to occur.

For certain patients, focused ultrasound could provide a noninvasive and possibly more effective alternative to conventional wound care. It may help avoid surgery, grafting or other invasive options, and it can be repeated, if necessary.<\/p>\n\n\n\n

Clinical Trials<\/h2>\n\n\n\n

At the present time, there are no clinical trials recruiting patients for focused ultrasound and chronic wound treatments.<\/p>\n\n\n\n

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here<\/strong><\/a>, it will take you to the latest information available from https:\/\/www.clinicaltrials.gov\/<\/strong><\/a>. <\/p>\n\n\n\n

Regulatory Approval and Reimbursement<\/h2>\n\n\n\n

Focused ultrasound treatment for wound healing is not yet approved by regulatory bodies or covered by medical insurance companies.<\/p>\n\n\n\n

Notable Papers<\/h2>\n\n\n\n

Bai Z, Li Z, Shao Y. Subcellular Cavitation Bubbles Induce Cellular Mechanolysis and Collective Wound Healing in Ultrasound-Inflicted Cell Ablation<\/strong><\/a>. Adv Sci (Weinh). 2025 Mar;12(11):e2410760. doi: 10.1002\/advs.202410760. Epub 2025 Jan 30. PMID: 39887946<\/p>\n\n\n\n

Calik J, Zawada T, Bove T, Dzi\u0119giel P, Pogorzelska-Antkowiak A, Mackiewicz J, Wo\u017aniak B, Sauer N. Healing\u202fProcess\u202fafter\u202fHigh-Intensity\u202fFocused\u202fUltrasound\u202fTreatment of Benign Skin Lesions: Dermoscopic Analysis and Treatment Guidelines<\/strong><\/a>. J Clin Med. 2024 Feb 6;13(4):931. doi: 10.3390\/jcm13040931. PMID:\u202f38398246 <\/p>\n\n\n\n

Matula TJ, Wang YN, Khokhlova T, Leotta DF, Kucewicz J, Brayman AA, Bruce M, Maxwell AD, MacConaghy BE, Thomas G, Chernikov VP, Buravkov SV, Khokhlova VA, Richmond K, Chan K, Monsky W. Treating Porcine Abscesses with Histotripsy: A Pilot Study<\/strong><\/a>. Ultrasound Med Biol. 2021 Mar;47(3):603-619. doi: 10.1016\/j.ultrasmedbio.2020.10.011. Epub 2020 Nov 26.<\/p>\n\n\n\n

Wardlow R, Sahoo K, Dugat D, Malayer J, Ranjan A. High Intensity Focused Ultrasound (HIFU) Heating Improves Perfusion and Antimicrobial Efficacy in Mouse Staphylococcus Abscess<\/strong><\/a>. Ultrasound Med Biol. January 2018. doi:10.1016\/j.ultrasmedbio.2017.12.014.

Wilson CG, Mart\u00edn-Saavedra FM, Padilla F, Fabiilli ML, Zhang M, Baez AM, Bonkowski CJ, Kripfgans OD, Voellmy R, Vilaboa N, Fowlkes JB, Franceschi RT. Patterning expression of regenerative growth factors using high intensity focused ultrasound<\/strong><\/a>. Tissue Eng Part C Methods. 2014 Oct;20(10):769-79. doi: 10.1089\/ten.TEC.2013.0518. Epub 2014 Mar 11. PMID: 24460731

Click here<\/a> for additional references from PubMed.<\/strong><\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"sw_disease_condition_cat":[29],"sw_disease_condition_stage":[14],"class_list":["post-3285","sw_disease_condition","type-sw_disease_condition","status-publish","hentry","sw_disease_condition_cat-miscellaneous"],"acf":[],"yoast_head":"\nChronic Wounds - Focused Ultrasound Foundation<\/title>\n<meta name=\"description\" content=\"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Chronic Wounds\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/chronic-wounds\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chronic Wounds - 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