{"id":3402,"date":"2021-12-08T20:24:00","date_gmt":"2021-12-08T20:24:00","guid":{"rendered":"https:\/\/fusfoundation.org\/?post_type=sw_disease_condition&#038;p=3402"},"modified":"2025-04-15T09:30:24","modified_gmt":"2025-04-15T13:30:24","slug":"headaches-2","status":"publish","type":"sw_disease_condition","link":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/headaches-2\/","title":{"rendered":"Headaches"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-focused-ultrasound-therapy\">Focused Ultrasound Therapy<\/h2>\n\n\n\n<p>Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with different types of headaches, including chronic migraine headaches. This novel technology focuses beams of ultrasonic energy precisely and accurately on targets deep in the brain without damaging surrounding normal tissue.<\/p>\n\n\n\n<p><strong>How It Works<\/strong><br>Where the beams converge, focused ultrasound can cause several different effects that can be helpful.<\/p>\n\n\n\n<p>In clinical use, there has been a single case report where thermal ablation of the nerve pathways have been ablated with good success.<\/p>\n\n\n\n<p>In preclinical models, use of FUS neuromodulation of the occipital nerves that has reduced the severity of headaches. <\/p>\n\n\n\n<p>While significant preclinical work has been accomplished, there is still much to be done before this technology will be widely available.<br><br><strong>Advantages<\/strong><br>The primary options for treatment of headaches include medication, many of which have side effects or are only partly effective. Possible advantages are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Focused ultrasound is non-invasive, so it does not carry added concerns like surgical wound healing or infection.<\/li>\n\n\n\n<li>Focused ultrasound can reach the desired target without damaging surrounding tissue.<\/li>\n\n\n\n<li>It can be repeated, if necessary.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials\">Clinical Trials<\/h2>\n\n\n\n<p>At the present time, there are no clinical trials recruiting patients for treatment of headaches.<\/p>\n\n\n\n<p>The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click <a href=\"https:\/\/clinicaltrials.gov\/search?cond=Headache&amp;term=focused%20ultrasound&amp;aggFilters=status:not%20rec\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>here<\/strong><\/a>, it will take you to the latest information available from <a href=\"https:\/\/www.clinicaltrials.gov\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/www.clinicaltrials.gov\/<\/strong><\/a>.\u00a0<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-regulatory-approval-and-reimbursement-nbsp\">Regulatory Approval and Reimbursement&nbsp;<\/h2>\n\n\n\n<p>Focused ultrasound treatment for headaches is not yet approved by regulatory bodies or covered by medical insurance companies.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-notable-papers\">Notable Papers<\/h2>\n\n\n\n<p>Yoon BC, Coetzee JP, Kang X, Brar R, Timmerman M, Harris O, Madrigal E, Adamson MM. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39566597\/\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"ek-link\"><strong>Low-intensity focused ultrasound (LIFU) for the treatment of post-traumatic headache (PTH) in veterans: A feasibility study<\/strong><\/a>. Brain Stimul. 2024 Nov 18;17(6):1290-1292. doi: 10.1016\/j.brs.2024.11.007. PMID: 39566597&nbsp;<\/p>\n\n\n\n<p>Magara AE, Gallay MN, Moser D, Jeanmonod D. <strong><a aria-label=\" (opens in a new tab)\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36443956\/\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"ek-link\">Complete resolution of chronic cluster headache following central lateral thalamotomy using incisionless MRI-guided&nbsp;focused&nbsp;ultrasound&nbsp;with 6 years of follow-up: illustrative case.<\/a><\/strong> J Neurosurg Case Lessons. 2022 Nov 28;4(22):CASE22259. doi: 10.3171\/CASE22259. Print 2022 Nov 28. &nbsp;<\/p>\n\n\n\n<p>Franzini A, Moosa S, D&#8217;Ammando A, Bono B, Scheitler-Ring K, Ferroli P, Messina G, Prada F, Franzini A.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30835002\/\" target=\"_blank\" rel=\"noreferrer noopener\">The neurosurgical treatment of craniofacial pain syndromes: current surgical indications and techniques.&nbsp;<\/a>Neurol Sci. 2019 May;40(Suppl 1):159-168. doi: 10.1007\/s10072-019-03789-4.<\/p>\n\n\n\n<p>Chiou JY, Abd-Elrehim T, Lin CC, Chen GS.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33146147\/\" target=\"_blank\" rel=\"noreferrer noopener\">Feasibility study of greater occipital nerve blocks by focused ultrasound &#8211; an animal study.<\/a>\u00a0J Neural Eng. 2020 Nov 4;17(5):056030. doi: 10.1088\/1741-2552\/abb14d.<br><em><br><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=(%22focused+ultrasound%22+OR+HIFU)+and+%22migraine%22\" target=\"_blank\" rel=\"noreferrer noopener\">Click here<\/a> for additional references from PubMed.<\/strong><\/em><\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":false,"_editorskit_reading_time":2,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"sw_disease_condition_cat":[6],"sw_disease_condition_stage":[20],"class_list":["post-3402","sw_disease_condition","type-sw_disease_condition","status-publish","hentry","sw_disease_condition_cat-neurological"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - 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