{"id":36439,"date":"2025-08-15T15:37:25","date_gmt":"2025-08-15T19:37:25","guid":{"rendered":"https:\/\/www.fusfoundation.org\/?post_type=sw_disease_condition&#038;p=36439"},"modified":"2025-08-15T15:52:29","modified_gmt":"2025-08-15T19:52:29","slug":"poisoning","status":"publish","type":"sw_disease_condition","link":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/","title":{"rendered":"Poisoning"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-focused-ultrasound-therapy-nbsp\">Focused Ultrasound Therapy&nbsp;<\/h2>\n\n\n\n<p>Focused ultrasound is a rapidly evolving, therapeutic technology that could transform the quality of life and decrease the cost of care for patients suffering from poisoning. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue.&nbsp;<\/p>\n\n\n\n<p><strong>How it Works\u00a0<\/strong><\/p>\n\n\n\n<p>Where the beams converge, focused ultrasound can produce temporary opening of the blood brain barrier (BBB), which prevents the accessing of the brain by therapeutic agents that can help with organic phosphates and warfare poisons. A preclinical study showed that the use of oximes in treatment of a supra-lethal dose of venomous agent X (a very toxic nerve gas) resulted in enhanced recovery from the treatment. While significant work has been accomplished, there is still much to be done before this technology will be widely available.&nbsp;<\/p>\n\n\n\n<p>The primary options for treatment of poisons involves the understanding of the type of the poison, and the ability to intervene in a timely manner.&nbsp;&nbsp;&nbsp;<\/p>\n\n\n\n<p>For certain patients, focused ultrasound could provide a non-invasive alternative option to patients who inadvertently are exposed to pesticides or to warfare poisons.&nbsp;&nbsp;<\/p>\n\n\n\n<p><strong>Advantages\u00a0<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Focused ultrasound is non-invasive, so it does not carry added concerns like surgical wound healing or infection.&nbsp;&nbsp;<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Focused ultrasound can reach the desired target without damaging surrounding tissue.&nbsp;<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>It can be repeated, if necessary.&nbsp;<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials-nbsp\">Clinical Trials&nbsp;<\/h2>\n\n\n\n<p>At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of organic poisons.&nbsp;&nbsp;<\/p>\n\n\n\n<p>The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click\u202f<a href=\"https:\/\/clinicaltrials.gov\/search?cond=Poisoning&amp;term=focused%20ultrasound&amp;aggFilters=status:not%20rec\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>here<\/strong><\/a>, it will take you to the latest information available from\u202f<a href=\"https:\/\/www.clinicaltrials.gov\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/www.clinicaltrials.gov\/<\/strong><\/a>.\u202f&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-regulatory-approval-and-reimbursement-nbsp-nbsp\">Regulatory Approval and Reimbursement&nbsp;&nbsp;<\/h2>\n\n\n\n<p>Focused ultrasound treatment for organic poisons is not yet approved by regulatory bodies or covered by medical insurance companies.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-notable-papers-nbsp\">Notable Papers&nbsp;<\/h2>\n\n\n\n<p>L\u00e9pinard L, Leterrier S, Jourdain L, Turri L, Belkebir A, Knoertzer J, Champault A, Bel R, Selingue E, M\u00e9riaux S, Larrat B, Tournier N, Bo GD, Thibault K, Novell A.<strong> <\/strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40500609\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Corrigendum to &#8220;Enhancing\u202foxime\u202fefficacy\u202finto\u202fbrain\u202fusing ultrasound to counteract nerve agent exposure&#8221; [Biomed. Pharmacother. 187 (2025) 118120].<\/strong><\/a><strong> <\/strong>Biomed Pharmacother. 2025 Jul;188:118233. doi: 10.1016\/j.biopha.2025.118233. Epub 2025 Jun 11. PMID:\u202f40500609<strong>\u202f<\/strong>&nbsp;<\/p>\n\n\n\n<p>Lucie L, Sarah L, Laur\u00e8ne J, Louise T, Assia B, Julie K, Alexandre C, Rosalie B, Erwan S, S\u00e9bastien M, Benoit L, Nicolas T, Gr\u00e9gory DB, Karine T, Anthony N. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40347846\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Enhancing\u202foxime\u202fefficacy\u202finto\u202fbrain\u202fusing ultrasound to counteract nerve agent exposure.<\/strong><\/a><strong> <\/strong>Biomed Pharmacother. 2025 Jun;187:118120. doi: 10.1016\/j.biopha.2025.118120. Epub 2025 May 9. PMID:\u202f40347846&nbsp;<\/p>\n\n\n\n<p>Kuca K, Valle da Silva JA, Nepovimova E, Pham NL, Wu W, Valis M, Wu Q, Fran\u00e7a TCC. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37788753\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Pralidoxime-like reactivator with increased lipophilicity &#8211; Molecular modeling and in vitro study.<\/strong><\/a><strong> <\/strong>Chem Biol Interact. 2023 Nov 1;385:110734. doi: 10.1016\/j.cbi.2023.110734. Epub 2023 Oct 1. PMID:\u202f37788753&nbsp;<\/p>\n\n\n\n<p>Andr\u00fds R, Kluso\u0148ov\u00e1 A, L\u00edsa M, Kassa J, Karasov\u00e1 J\u017d.<strong> <\/strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34019427\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Effect of\u202fOxime\u202fEncapsulation on Acetylcholinesterase Reactivation: Pharmacokinetic Study of the Asoxime-Cucurbit[7]uril Complex in Mice Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry.<\/strong><\/a><strong> <\/strong>Mol Pharm. 2021 Jun 7;18(6):2416-2427. doi: 10.1021\/acs.molpharmaceut.1c00257. Epub 2021 May 21. PMID:\u202f34019427&nbsp;<\/p>\n\n\n\n<p><strong>Click<\/strong> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=enhancing+oxime+efficacy+into+brain&amp;sort=date\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>here<\/strong><\/a><strong>\u202ffor additional references from PubMed.&nbsp;&nbsp;<\/strong>&nbsp;<\/p>\n","protected":false},"template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"sw_disease_condition_cat":[6],"sw_disease_condition_stage":[14],"class_list":["post-36439","sw_disease_condition","type-sw_disease_condition","status-publish","hentry","sw_disease_condition_cat-neurological"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Poisoning - Focused Ultrasound Foundation<\/title>\n<meta name=\"description\" content=\"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Poisoning\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Poisoning - Focused Ultrasound Foundation\" \/>\n<meta property=\"og:description\" content=\"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Poisoning\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/\" \/>\n<meta property=\"og:site_name\" content=\"Focused Ultrasound Foundation\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-15T19:52:29+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/\",\"url\":\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/\",\"name\":\"Poisoning - Focused Ultrasound Foundation\",\"isPartOf\":{\"@id\":\"https:\/\/www.fusfoundation.org\/#website\"},\"datePublished\":\"2025-08-15T19:37:25+00:00\",\"dateModified\":\"2025-08-15T19:52:29+00:00\",\"description\":\"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Poisoning\",\"breadcrumb\":{\"@id\":\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.fusfoundation.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Poisoning\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.fusfoundation.org\/#website\",\"url\":\"https:\/\/www.fusfoundation.org\/\",\"name\":\"Focused Ultrasound Foundation\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.fusfoundation.org\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.fusfoundation.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.fusfoundation.org\/#organization\",\"name\":\"Focused Ultrasound Foundation\",\"url\":\"https:\/\/www.fusfoundation.org\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.fusfoundation.org\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/cdn.fusfoundation.org\/2023\/08\/24140306\/focused-ultrasound-foundation-logo.png\",\"contentUrl\":\"https:\/\/cdn.fusfoundation.org\/2023\/08\/24140306\/focused-ultrasound-foundation-logo.png\",\"width\":730,\"height\":76,\"caption\":\"Focused Ultrasound Foundation\"},\"image\":{\"@id\":\"https:\/\/www.fusfoundation.org\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Poisoning - Focused Ultrasound Foundation","description":"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Poisoning","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/","og_locale":"en_US","og_type":"article","og_title":"Poisoning - Focused Ultrasound Foundation","og_description":"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Poisoning","og_url":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/","og_site_name":"Focused Ultrasound Foundation","article_modified_time":"2025-08-15T19:52:29+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/","url":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/","name":"Poisoning - Focused Ultrasound Foundation","isPartOf":{"@id":"https:\/\/www.fusfoundation.org\/#website"},"datePublished":"2025-08-15T19:37:25+00:00","dateModified":"2025-08-15T19:52:29+00:00","description":"Learn how focused ultrasound, a noninvasive therapeutic technology, is being investigated to address Poisoning","breadcrumb":{"@id":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.fusfoundation.org\/diseases-and-conditions\/poisoning\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.fusfoundation.org\/"},{"@type":"ListItem","position":2,"name":"Poisoning"}]},{"@type":"WebSite","@id":"https:\/\/www.fusfoundation.org\/#website","url":"https:\/\/www.fusfoundation.org\/","name":"Focused Ultrasound Foundation","description":"","publisher":{"@id":"https:\/\/www.fusfoundation.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.fusfoundation.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.fusfoundation.org\/#organization","name":"Focused Ultrasound Foundation","url":"https:\/\/www.fusfoundation.org\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.fusfoundation.org\/#\/schema\/logo\/image\/","url":"https:\/\/cdn.fusfoundation.org\/2023\/08\/24140306\/focused-ultrasound-foundation-logo.png","contentUrl":"https:\/\/cdn.fusfoundation.org\/2023\/08\/24140306\/focused-ultrasound-foundation-logo.png","width":730,"height":76,"caption":"Focused Ultrasound Foundation"},"image":{"@id":"https:\/\/www.fusfoundation.org\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/sw_disease_condition\/36439","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/sw_disease_condition"}],"about":[{"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/types\/sw_disease_condition"}],"version-history":[{"count":2,"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/sw_disease_condition\/36439\/revisions"}],"predecessor-version":[{"id":36477,"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/sw_disease_condition\/36439\/revisions\/36477"}],"wp:attachment":[{"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/media?parent=36439"}],"wp:term":[{"taxonomy":"sw_disease_condition_cat","embeddable":true,"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/sw_disease_condition_cat?post=36439"},{"taxonomy":"sw_disease_condition_stage","embeddable":true,"href":"https:\/\/www.fusfoundation.org\/wp-json\/wp\/v2\/sw_disease_condition_stage?post=36439"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}