{"id":531,"date":"2022-03-24T17:07:39","date_gmt":"2022-03-24T21:07:39","guid":{"rendered":"https:\/\/fusfoundation.org\/the-technology\/overview\/"},"modified":"2026-02-19T14:13:34","modified_gmt":"2026-02-19T18:13:34","slug":"overview","status":"publish","type":"page","link":"https:\/\/www.fusfoundation.org\/the-technology\/overview\/","title":{"rendered":"Overview"},"content":{"rendered":"<div\n    class=\"sw-block sw-block-interior-hero    block md:block lg:block alignfull overflow-hidden my-4 md:my-8\"\n    \n    id=\"block_ee38009c5deec3a655b199697a231c63\"\n>\n    \n<section class=\"not-prose relative\">\n            \n        <div class=\"min-h-[215px] w-full bg-cover bg-center bg-no-repeat py-6 md:min-h-[350px] md:py-16 md:rounded-br-[80px]\" style=\"background-image:url('https:\/\/cdn.fusfoundation.org\/2024\/09\/30174207\/Brain-images_cropped.png')\" role=\"img\" aria-label=\"\">\n            <div class=\"px-3.5 pb-4 md:pb-16\">\n                <div class=\"mx-auto max-w-7xl\">\n                  <div class=\"relative max-w-3xl bg-brand-primary-blueDark py-5 pr-5 md:pt-7 md:pb-8 md:pr-16 before:absolute before:left-0 before:top-0 before:h-full before:w-full before:-translate-x-full before:bg-brand-primary-blueDark rounded-tr-[60px] md:rounded-tr-[80px]\">\n                                                <h1 class=\"text-white text-[28px] leading-[1.15] md:text-[52px] md:leading-[1.15]\">Focused Ultrasound<\/h1>\n                                    \n                                                <p class=\"text-white leading-tight md:text-[22px] md:leading-tight mt-2\">It is the most powerful sound you will never hear, but a sound that could save your life. Sooner or later, you, a friend, or a pet, will develop a condition that could be treated with focused ultrasound. <\/p>\n                                        <\/div>\n                <\/div>\n              <\/div>\n        <\/div>\n    \n<\/div>\n\n\n<div\n    class=\"sw-block sw-block-banner-hero    block md:block lg:block alignfull overflow-hidden my-4 md:my-8\"\n    \n    id=\"block_d1ad903d38074c08d7e342fad7a7c8a4\"\n>\n    \n<section class=\"not-prose grid\">\n            <div class=\"\">\n    <div class=\"sw-alignwide\">\n        <div\n            class=\"relative max-w-5xl bg-white pb-6 pt-4 before:absolute before:left-0 before:top-0 before:h-full before:w-full before:-translate-x-full before:bg-white md:rounded-tr-[80px]\">\n                            <div class=\"flex items-baseline\">\n                    <span><a href=\"https:\/\/www.fusfoundation.org\/\" class=\"text-sm font-light leading-none md:text-base md:leading-none transition hover:text-brand-primary-blue focus:text-brand-primary-blue\">Home<\/a><\/span>\n                <\/div>\n                    <\/div>\n    <\/div>\n<\/div>\n      \n    \n<\/section>\n<\/div>\n\n\n<div\n    class=\"sw-block sw-block-text-callout    block md:block lg:block  overflow-hidden \"\n    \n    id=\"block_b02193aa74f8b15f1ea4e33fd6d3c76d\"\n>\n    \n<section class=\"\">\n    <div class=\"\">\n        <div>\n                            <h3>Focused ultrasound is an early-stage but rapidly evolving, revolutionary, therapeutic technology with the potential to transform the treatment of many medical disorders by using ultrasonic energy to target tissue deep in the body noninvasively.<\/h3>\n                    \n                            <p>Focused ultrasound is being researched as an alternative or complement to traditional surgery and radiation therapy. It is also a new way to deliver drugs more effectively and to enhance cancer immunotherapy. It has the potential to be an outpatient\u200b therapy with no incisions\u200b, meaning a more rapid recovery and fewer complications\u200b such as infection\u200b, hemorrhage\u200b, or tissue damage.<\/p>\n\n                    <\/div>\n        \n            <\/div>\n\n<\/section>\n\n<\/div>\n\n\n<div\n    class=\"sw-block sw-block-floating-content    block md:block lg:block alignfull overflow-hidden my-4 md:my-8\"\n    \n    id=\"block_7242fc2c7409f5192ec799cf049b8212\"\n>\n    \n<section class=\"\" x-data=\"{ open: false }\">\n    <div class=\"md:py-10 grid\">\n        <div class=\"hidden md:grid grid-cols-2 [grid-column:1] [grid-row:1] h-full w-full\">\n            <div class=\"md:py-16 relative md:order-first bg-brand-primary-blueDark md:before:absolute md:before:top-0 md:before:h-full md:before:w-20 md:before:bg-brand-primary-blueDark p-4 flex flex-col justify-center md:before:right-0 md:before:translate-x-full\"><\/div>\n            <div class=\"\"><\/div>\n        <\/div>\n        <div class=\"md:grid md:grid-cols-2 [grid-column:1] [grid-row:1] gap-8 max-w-[1160px] mx-auto\">\n            <div class=\"md:-translate-y-10 not-prose relative rounded-tl-[60px] md:rounded-tl-[80px] md:rounded-br-[80px] overflow-hidden z-10 [@media(min-width:1360px)]:-mr-20\">\n                                    <img decoding=\"async\" class=\"object-cover w-full h-full\" src=\"https:\/\/cdn.fusfoundation.org\/2024\/09\/26135544\/2024-09-26-13_54_58-Window.png\" alt=\"\" \/>\n                                \n                                    <button class=\"absolute inset-0 flex justify-center items-center text-brand-primary-blueDark group cursor-pointer\" @click=\"open = true\">\n                        <span class=\"sr-only\">Click to open video<\/span>\n                        <div class=\"group-hover:hover:bg-white\/100 transition bg-white\/90 rounded-full w-32 h-32 flex items-center justify-center\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 24 24\" fill=\"currentColor\" class=\"w-20 h-20 ml-3\">\n                                <path fill-rule=\"evenodd\" d=\"M4.5 5.653c0-1.427 1.529-2.33 2.779-1.643l11.54 6.347c1.295.712 1.295 2.573 0 3.286L7.28 19.99c-1.25.687-2.779-.217-2.779-1.643V5.653Z\" clip-rule=\"evenodd\" \/>\n                            <\/svg>                      \n                        <\/div>\n                    <\/button>\n                            <\/div>\n            <div class=\"px-4 md:order-first relative z-10 md:py-16 bg-brand-primary-blueDark md:bg-transparent p-4 2xl:px-0\">\n                <div class=\"not-prose\">\n                                            <h2 class=\"text-white font-light text-[26px] leading-none mb-4 md:text-[40px] md:leading-tight\">How It Works<\/h2>\n                                    <\/div>\n\n                                    <div class=\"prose [&#038;_*]:text-white hover:prose-a:text-gray-300 focus:prose-a:text-gray-300 prose-a:underline prose-a:transition [&#038;_li::marker]:text-white prose-p:text-white prose-p:text-lg prose-strong:text-white prose-p:leading-normal md:prose-p:text-xl md:prose-p:leading-normal prose-p:px-0 prose-ul:px-5\">\n                        <p><!-- wp:paragraph --><\/p>\n<p id=\"block-b0c031e1-b995-4ae9-9f08-fe792878489d\">The principle is analogous to using a magnifying glass to focus beams of light to burn a hole in a leaf. With focused ultrasound, an acoustic lens is used to concentrate intersecting beams of ultrasound on a target deep in the body with precision and accuracy, causing a profound effect at point of convergence while adjacent tissue is spared.<\/p>\n<p>It is the integration of two innovative technologies. Magnetic resonance or ultrasound imaging is used to target the tissue to be treated, guide, and control the treatment in real time.<\/p>\n<p><!-- \/wp:paragraph --><\/p>\n\n                    <\/div>\n                \n                \n                            <\/div>\n        <\/div>\n    <\/div>\n\n        <div\n        x-show=\"open\"\n        style=\"display: none\"\n        x-on:keydown.escape.prevent.stop=\"open = false\"\n        role=\"dialog\"\n        aria-modal=\"true\"\n        x-id=\"['modal-title']\"\n        :aria-labelledby=\"$id('modal-title')\"\n        class=\"not-prose fixed inset-0 z-10 overflow-y-auto\"\n    >\n        <div x-show=\"open\" x-transition.opacity class=\"fixed inset-0 bg-black\/60\"><\/div>\n\n        <div\n            x-show=\"open\" x-transition\n            x-on:click=\"open = false\"\n            class=\"relative flex min-h-screen items-center justify-center p-4\"\n        >\n            <div\n                x-on:click.stop\n                x-trap.noscroll.inert=\"open\"\n                class=\"relative w-full max-w-7xl overflow-y-auto bg-white p-6 pt-3.5 md:p-14 md:pt-3.5 shadow-lg border border-brand-neutral-gray\"\n            >\n                <button type=\"button\" x-on:click=\"open = false\" class=\"flex justify-end text-brand-primary-blue rounded ml-auto mb-2\">\n                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" viewBox=\"0 0 24 24\" stroke-width=\"1.5\" stroke=\"currentColor\" class=\"w-10 h-10\">\n                        <path stroke-linecap=\"round\" stroke-linejoin=\"round\" d=\"M6 18 18 6M6 6l12 12\" \/>\n                    <\/svg>\n                <\/button>\n\n                <div class=\"max-w-3xl mx-auto\">\n                                            <template x-if=\"open\">\n                            <div>\n                                <iframe loading=\"lazy\" title=\"Focused Ultrasound Technology\" width=\"640\" height=\"480\" src=\"https:\/\/www.youtube.com\/embed\/GLAh7u7ihc4?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n                            <\/div>\n                        <\/template>\n                            \n                    \n                    <div class=\"mt-5\">\n                        \n                                            <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <\/section>\n\n<\/div>\n\n\n\n<p id=\"block-b0c031e1-b995-4ae9-9f08-fe792878489d\">Depending on the design of the lens and the ultrasound parameters, the target can be as small as 1\u00d71.5mm or as large as 10x16mm in diameter. Where each of the individual beams passes through the tissue, there is no effect. But, at the focal point, the convergence of the multiple beams of focused ultrasound energy results in many important biological effects, creating the possibility of treating a variety of medical disorders.&nbsp;<\/p>\n\n\n<div class=\"md:hidden\" style=\"height: 20px;\"><\/div>\n\n    <div class=\"hidden md:block\" style=\"height: 60px;\"><\/div>\n\n\n<div\n    class=\"sw-block sw-block-call-to-action    block md:block lg:block alignfull overflow-hidden my-4 md:my-8\"\n    \n    id=\"block_719627f3b45be92cca4f2c3576461d68\"\n>\n    \n\n<section class=\"not-prose relative\">\n            <img decoding=\"async\" class=\"object-cover absolute inset-0 w-full h-full\" src=\"https:\/\/cdn.fusfoundation.org\/2022\/04\/08153245\/stock-brain-blue-scaled.jpg\" alt=\"\" \/>\n    \n    <div class=\"max-w-[810px] mx-auto px-3.5 py-20 md:py-24 z-10 relative\">\n        <div class=\"mx-auto bg-white text-center rounded-tr-[80px] rounded-bl-[80px] px-12 py-7 md:px-14 md:py-24\">\n                            <h2 class=\"text-brand-primary-blue font-light text-[26px] leading-none mb-4 md:mb-2.5 md:text-[40px] md:leading-tight\">Mechanisms of Action<\/h2>\n            \n                            <p class=\"text-black text-lg leading-normal md:text-xl md:leading-normal\">Focused ultrasound is a platform technology that can produce multiple biological effects. Today, there are nearly 30 identified mechanisms of action by which the technology can impact tissue, creating the possibility to treat a variety of disorders. <\/p>\n                        \n                            <div class=\"mt-6\">\n                                                                        <a class=\"inline-block w-full text-white bg-brand-primary-blue text-sm font-semibold tracking-wider text-center leading-none py-4 px-8 rounded-3xl border uppercase border-transparent outline outline-transparent outline-2 -outline-offset-2  hover:bg-brand-primary-blueDark focus-visible:bg-brand-accent-orange active:bg-brand-accent-turquoise active:border-white active:outline-transparent disabled:pointer-events-none disabled:cursor-default disabled:bg-neutral-200 md:w-auto\" href=\"https:\/\/www.fusfoundation.org\/the-technology\/mechanisms-of-focused-ultrasound\/\" target=\"_self\" title=\"LEARN MORE\">LEARN MORE<\/a>\n                                                            <\/div>\n                    <\/div>\n    <\/div>\n<\/section>\n\n<\/div>\n\n\n<div class=\"md:hidden\" style=\"height: 20px;\"><\/div>\n\n    <div class=\"hidden md:block\" style=\"height: 60px;\"><\/div>\n\n\n<div\n    class=\"sw-block sw-block-link-list    block md:block lg:block  overflow-hidden my-4 md:my-8\"\n    \n    id=\"block_9ef47d97c802cc6c8ef0e7cffc7d2eb1\"\n>\n    \n<section class=\"not-prose\">\n    <div class=\"\">\n        <div class=\"md:grid md:grid-cols-2 md:gap-12\">\n            <div>\n                                    <h2 class=\"text-brand-primary-blue font-light text-[26px] leading-none mb-4 md:mb-2.5 md:text-[40px] md:leading-tight\">Technology Resources<\/h2>\n                            <\/div>\n            <div>\n                                                                                        <div>\n                                <a class=\"border-t-2 border-b-2 border-brand-neutral-grayLight px-3 py-5 text-lg font-medium leading-none text-black inline-flex items-center justify-between w-full md:text-[22px] md:leading-[1.15] group transition hover:text-brand-primary-blue focus-visible:text-brand-accent-orange active:text-brand-accent-turquoise disabled:pointer-events-none disabled:cursor-default disabled:bg-neutral-200\" href=\"https:\/\/www.fusfoundation.org\/the-technology\/state-of-the-field-report\/\" target=\"_self\" title=\"State of the Field\">State of the Field\n                                    \n                                <\/a>\n                            <\/div>\n                                                                                                <div>\n                                <a class=\" border-b-2 border-brand-neutral-grayLight px-3 py-5 text-lg font-medium leading-none text-black inline-flex items-center justify-between w-full md:text-[22px] md:leading-[1.15] group transition hover:text-brand-primary-blue focus-visible:text-brand-accent-orange active:text-brand-accent-turquoise disabled:pointer-events-none disabled:cursor-default disabled:bg-neutral-200\" href=\"https:\/\/www.fusfoundation.org\/the-technology\/state-of-research-and-regulatory-authorizations\/\" target=\"_self\" title=\"State of Research and Regulatory Authorizations\">State of Research and Regulatory Authorizations\n                                    \n                                <\/a>\n                            <\/div>\n                                                                                                <div>\n                                <a class=\" border-b-2 border-brand-neutral-grayLight px-3 py-5 text-lg font-medium leading-none text-black inline-flex items-center justify-between w-full md:text-[22px] md:leading-[1.15] group transition hover:text-brand-primary-blue focus-visible:text-brand-accent-orange active:text-brand-accent-turquoise disabled:pointer-events-none disabled:cursor-default disabled:bg-neutral-200\" href=\"\/the-technology\/manufacturers\/\" target=\"_self\" title=\"Manufacturers\">Manufacturers\n                                    \n                                <\/a>\n                            <\/div>\n                                                                                                <div>\n                                <a class=\" border-b-2 border-brand-neutral-grayLight px-3 py-5 text-lg font-medium leading-none text-black inline-flex items-center justify-between w-full md:text-[22px] md:leading-[1.15] group transition hover:text-brand-primary-blue focus-visible:text-brand-accent-orange active:text-brand-accent-turquoise disabled:pointer-events-none disabled:cursor-default disabled:bg-neutral-200\" href=\"\/the-technology\/fus-partners\/\" target=\"_self\" title=\"FUS Partners\">FUS Partners\n                                    \n                                <\/a>\n                            <\/div>\n                                                                                                <div>\n                                <a class=\" border-b-2 border-brand-neutral-grayLight px-3 py-5 text-lg font-medium leading-none text-black inline-flex items-center justify-between w-full md:text-[22px] md:leading-[1.15] group transition hover:text-brand-primary-blue focus-visible:text-brand-accent-orange active:text-brand-accent-turquoise disabled:pointer-events-none disabled:cursor-default disabled:bg-neutral-200\" href=\"\/the-technology\/meet-the-experts\/\" target=\"_self\" title=\"Meet the Experts\">Meet the Experts\n                                    \n                                <\/a>\n                            <\/div>\n                                                                                                <div>\n                                <a class=\" border-b-2 border-brand-neutral-grayLight px-3 py-5 text-lg font-medium leading-none text-black inline-flex items-center justify-between w-full md:text-[22px] md:leading-[1.15] group transition hover:text-brand-primary-blue focus-visible:text-brand-accent-orange active:text-brand-accent-turquoise disabled:pointer-events-none disabled:cursor-default disabled:bg-neutral-200\" href=\"\/the-technology\/intellectual-property\/\" target=\"_self\" title=\"Intellectual Property and Patents\">Intellectual Property and Patents\n                                    \n                                <\/a>\n                            <\/div>\n                                                                                                <div>\n                                <a class=\" border-b-2 border-brand-neutral-grayLight px-3 py-5 text-lg font-medium leading-none text-black inline-flex items-center justify-between w-full md:text-[22px] md:leading-[1.15] group transition hover:text-brand-primary-blue focus-visible:text-brand-accent-orange active:text-brand-accent-turquoise disabled:pointer-events-none disabled:cursor-default disabled:bg-neutral-200\" href=\"\/the-technology\/market-reports\/\" target=\"_self\" title=\"Market Reports\">Market Reports\n                                    \n                                <\/a>\n                            <\/div>\n                                                                        <\/div>\n        <\/div>\n    <\/div>\n<\/section>\n    \n<\/div>\n\n\n<div class=\"md:hidden\" style=\"height: 20px;\"><\/div>\n\n    <div class=\"hidden md:block\" style=\"height: 60px;\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-timeline-of-focused-ultrasound\"><a href=\"\/the-technology\/timeline-of-focused-ultrasound\/\" class=\"ek-link\">Timeline of Focused Ultrasound<\/a><\/h2>\n\n\n<div\n    class=\"sw-block sw-block-timeline    block md:block lg:block alignfull overflow-hidden my-4 md:my-8\"\n    \n    id=\"block_75283a4897d94664b552bf4a76d72609\"\n>\n    \n    <section class=\"not-prose\">\n        <div class=\"max-w-[1440px] mx-auto px-3.5\">\n            <div class=\"mb-5 text-black text-xs tracking-widest leading-none md:text-sm md:leading-none uppercase flex items-center justify-center md:justify-start\">\n                <span class=\"mt-0.5\">Scroll To Explore Timeline<\/span>\n                <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" viewBox=\"0 0 24 24\" stroke-width=\"1.5\" stroke=\"currentColor\" class=\"w-5 h-5 ml-2\">\n                    <path stroke-linecap=\"round\" stroke-linejoin=\"round\" d=\"M13.5 4.5 21 12m0 0-7.5 7.5M21 12H3\" \/>\n                <\/svg>\n            <\/div>\n            <div class=\"swiper timelineSwiper !overflow-visible\">\n                <div class=\"swiper-wrapper\">\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1880\">1880<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Discovery of Ultrasound Technology<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Pierre Curie and his brother, Jacques Curie, discovered the piezoelectric effect in certain crystals in Paris, France, leading to the evolution of high frequency echo-sounding techniques.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1915\">1915<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Ultrasound Device<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">French professor Paul Langevin and Swiss physicist Constantin Chilowsky developed a high-frequency ultrasonic device called a hydrophone, which was used in German U-boat and submarine surveillance.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1917\">1917<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Paul Langevin Discovery<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Paul Langevin discovered that a water tank insonated with high-intensity ultrasound killed fish immediately, and certain observers experienced \u201ca painful sensation on plunging the hand in this region.\u201d<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1932\">1932<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Thought of Therapeutic Use for Ultrasound<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">H. Freundlich, K. Collner, and F. Rogowski suggested the application of ultrasound to therapeutically heat tissue.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1935\">1935<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Focusing of Ultrasound<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Johannes Gruetzmacher found that an ultrasound could be focused when he placed a concave surface to a piezoelectric generator.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1942\">1942<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Tissue Lesion<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">John G. Lynn et al. proposed the idea that ultrasound could be intensely focused to produce extreme heat and non-invasively destroy targeted diseased tissue within the body. They were able to produce lesions deep in bovine liver without damaging surrounding tissue.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1942\">1942<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Focused Ultrasound Device<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Brothers William and Francis Fry and a research team developed a focused ultrasound device that mechanically aligned four focused ultrasound generators to produce a pinpoint lesion without damage to the surrounding tissue.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1944\">1944<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Preclinical Study<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">John G. Lynn and Tracy J. Putcham were able to destroy cerebral tissue in animals using focused ultrasound. They treated 37 animals in all and found well-circumscribed lesions on physical examination of the areas.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1950\">1950<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Therapeutic Use<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Lars Leksell designed a specially adapted frame and ultrasound transducer for the purpose of focused ultrasound lesioning and successfully used it on patients to treat psychiatric disorders. He eventually abandoned the method due to lack of imaging and the need for craniotomies.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1952\">1952<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Focused Ultrasound Meeting<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The first major symposium on Ultrasound in Biology and Medicine was held at the University of Illinois to examine phenomena of how ultrasonic energy interacted with and acted upon biological materials.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1954\">1954<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Focused Ultrasound as Lobotomy Alternative<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Petter A. Lindstrom studied the effects of focused ultrasound-mediated lesioning as an alternative to a lobotomy procedure in patients with carcinomatosis and cancer-related pain.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1955\">1955<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">The \u201cFathers\u201d of Focused Ultrasound<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Brothers William and Francis Fry performed a partial ablation of the basal ganglia after a craniotomy using focused ultrasound.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1957\">1957<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Research Group Dedicated to Focused Ultrasound<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">William Fry, Francis Fry, and Reginald C. Eggleton founded the Interscience Research Institute to develop high-intensity ultrasound instrumentation to treat neurological disorders and computer-based, low-intensity ultrasound instrumentation for visualization of soft tissue.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1962\">1962<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Focused Ultrasound and the Brain<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Russell Meyers and William Fry utilized focused ultrasound to treat numerous human patients suffering from various brain pathologies, in particular Parkinson\u2019s disease.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1964\">1964<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Cancer Application<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">M. Oka reported on the successful use of focused ultrasound to treat thyroid and breast cancers.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1968\">1968<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Brain Cancer Treatment<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Dr. Robert Heimburger was the first neurosurgeon to use a focused ultrasound device to treat brain cancer, under ultrasound guidance.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1972\">1972<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">HIFU Ablative Research by Francis Fry and Colleagues<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Between 1972 and 1984, Francis Fry and colleagues continued to carry out laboratory research on focused ultrasound for solid tumors in preclinical models.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1988\">1988<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First FDA Approval<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Coleman and Lizzie developed the Sonocare CST-100 Therapeutic Ultrasound System which was designed to treat glaucoma. It was the first focused ultrasound system to earn FDA approval. However, it was ultimately outdated by laser surgery.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1990\">1990<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Focused Ultrasound for BPH<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">N. Sanghvi et al. developed and implemented a clinical protocol for focused ultrasound treatment of benign prostatic hyperplasia.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1991\">1991<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Focused Ultrasound for Brain Tumors<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">A. Guthkelch and K. Hynynen et al. reported on the treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1992\">1992<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Combination with MRI<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">K. Hynynen et al. proposed the use of noninvasive focused ultrasound using magnetic resonance imaging to guide and monitor tissue damage. The term Magnetic Resonance Guided Focused Ultrasound (MRgFUS) was first coined.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1996\">1996<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Blood-brain Barrier Application<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">K. Hynynen et al. first described a controlled, reversible, and reproducible manner of opening the blood-brain barrier, monitored by MRI.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1998\">1998<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Transcranial Research<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">K. Hynynen and F. Jolesz demonstrated the feasibility of using a large phased array applicator for through skull focusing and ablation and proposed the benefits of using cavitation for through skull treatments.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"1999\">1999<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Volumetric Hyperthermia with MR-guided Focused Ultrasound<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">C. Moonen and colleagues demonstrate volumetric heating for local hyperthermia with MR-guided focused ultrasound and real time temperature feedback in preclinical studies.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2001\">2001<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Focused Ultrasound Society<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The International Society for Therapeutic Ultrasound (ISTU) was formed to increase and diffuse knowledge of therapeutic ultrasound to the scientific and medical community.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2001\">2001<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Breakthroughs in Brain Research<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">K. Hynynen et al. determined that focused ultrasound plus microbubbles can disrupt the blood brain barrier (BBB), a historically major obstacle in the treatment of brain diseases.\r\n\r\nG. Clement and K. Hynynen demonstrated noninvasive focusing through human skull using a phased array and CT based planning algorithm.\r\n<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2003\">2003<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Clinical Trials in Women\u2019s Health<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">C. Tempany et al. performed the first clinical trial of uterine fibroids using INSIGHTEC\u2019S Exablate system and found the procedure feasible and safe.\r\n\r\nF. Wu et al. performed the first focused ultrasound clinical trial for breast cancer, concluding it could be effective, safe, and feasible in the extracorporeal treatment of localized disease.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2003\">2003<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Focused Ultrasound and Immune Response<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">H. Zheng et al. found focused ultrasound treatment may evoke a strong immune response to combat residual tumor cells and suppress remote metastasis in cancer patients.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2004\">2004<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First US Approval of an MRgFUS Device<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The FDA approved INSIGHTEC\u2019s Exablate 2000 to treat uterine fibroids.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2006\">2006<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Foundation Began<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The Focused Ultrasound Foundation was founded in Charlottesville, Virginia, to help accelerate the development and adoption of focused ultrasound.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2006\">2006<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Brain Clinical Trial<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Z. Ram et al. initiated a clinical trial to treat patients with recurrent gliomas and demonstrated that it was a potentially effective way of destroying tissue.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2007\">2007<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Demonstrating Drug Delivery<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">L. Treat et al. demonstrated chemotherapy delivery (Doxil) into the brain.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2008\">2008<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Philips Enters the Industry<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Philips unveiled MRgFUS system Sonalleve, initially used to treat uterine fibroids.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2008\">2008<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Focused Ultrasound Foundation Symposium<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The Focused Ultrasound Foundation hosted the first biennial Focused Ultrasound Symposium, October 6-7, 2008, in Tyson\u2019s Corner, Virginia. The meeting attracted 300 attendees from around the world.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2009\">2009<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Focused Ultrasound for Pain<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">E. Martin, D. Jeanmonod et al. conducted successful clinical trials that used focused ultrasound targeting the thalamus to treat neuropathic pain.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2010\">2010<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Movement Disorder Trial<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">W. Elias et al. successfully treated the first 15 patients with essential tremor at the University of Virginia in a pilot trial. All patients noted a significant decrease in their tremors.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2012\">2012<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Regulatory Wins<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The FDA approved focused ultrasound for the treatment of pain from bone metastases.\r\n\r\nTheraclion\u2019s EchoPulse received CE marking in Europe to treat breast fibroadenoma.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2013\">2013<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Addressing Challenging Cancers<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">M. Aryal, Y. Zhang et al. demonstrated that focused ultrasound can enhance delivery of anti-cancer drugs (Doxirubicin) and have a therapeutic effect on gliomas in a rat model.\r\n\r\nHF. Gao et al. performed the first clinical trial using focused ultrasound to treat local advanced pancreatic cancer.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2014\">2014<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Focused Ultrasound for Bone Cancer Pain<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Hurwitz et al. demonstrated that MRgFUS is a safe, effective, and noninvasive treatment for alleviating pain resulting from bone metastases.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2014\">2014<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Pediatric Patient in North America<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The first pediatric osteoid osteoma (bone tumor) was treated in a clinical trial conducted by The Hospital for Sick Children (SickKids) and Sunnybrook Health Sciences Centre. The Foundation funded the trial.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2015\">2015<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Depression Clinical Trial Begins<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The first patient with depression was treated in a focused ultrasound clinical trial led by Jin Woo Chang, MD, at Yonsei University College of Medicine in Seoul, Korea.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2015\">2015<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First-in-Man Hyperthermia Treatment with MR-guided Focused Ultrasound<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">W. Chu, in the Department of Radiation Oncology at Sunnybrook Health Sciences Centre in Toronto, reported the feasibility and safety of MR-guided focused ultrasound hyperthermia in a pilot study on 10 patients with recurrent rectal cancer.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2015\">2015<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Approvals to Treat the Prostate<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Two focused ultrasound devices \u2013 EDAP\u2019s Ablatherm Robotic HIFU and SonaCare Medical\u2019s Sonablate 450 \u2013 earned FDA approval to ablate prostate tissue. This technique could be used to treat conditions like prostate cancer and BPH.\r\n\r\n<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2016\">2016<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">John Grisham\u2019s Focused Ultrasound Book<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">John Grisham wrote \u201cThe Tumor,\u201d a book about the potential for focused ultrasound, to raise awareness of the technology. In a year, more than 800,000 copies were distributed.\r\n\r\nIn 2019, the audiobook version of the book was released, pushing the number of total books distributed over 1 million.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2016\">2016<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Essential Tremor Approval<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Insightec\u2019s Exablate Neuro device is approved to treat essential tremor in the US and Canada. The Centers for Medicare and Medicaid Services subsequently assigned the procedure a payment level, the first step toward Medicare reimbursement.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2017\">2017<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Focused Ultrasound Pediatric Brain Tumor Clinical Trial Begins<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">A team at Nicklaus Children\u2019s Hospital in Miami, Florida, treated the first patient in a pediatric and young adult brain tumor study.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2017\">2017<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Alzheimer\u2019s Disease Trial<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The first clinical trial for Alzheimer\u2019s disease began in Toronto, Canada. The trial was one of the first to explore using focused ultrasound to temporarily disrupt the blood-brain barrier (BBB).<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2017\">2017<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Partnering on Immunotherapy<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The Foundation and the Cancer Research Institute partnered to further focused ultrasound and immunotherapy combination approaches to treat cancer.\r\n\r\nThe first clinical trial combining focused ultrasound with an immunotherapy drug also began for patients with metastatic breast cancer in Virginia.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2017\">2017<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Veterinary Applications<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The Foundation launched a veterinary program and funded initial trials in canine cancer and wound healing.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2017\">2017<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Profound Medical Transforms Industry<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Toronto-based Profound Medical announced that it will acquire Philips\u2019 Sonalleve MR-HIFU business.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2018\">2018<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Histotripsy Clinical Trial<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">A first-in-human clinical trial \u2013 the \u201cTHERESA\u201d study \u2013 took place at three sites in Barcelona, Spain, under the direction of Joan Vidal-Jov\u00e9, MD, PhD, Head of Focused Ultrasound Ablation Oncology at Barcelona University Hospital.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2018\">2018<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Focused Ultrasound Drug Delivery Clinical Trial Published<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The first clinical trial demonstrating local drug delivery using focused ultrasound and temperature sensitive liposomes was performed in Oxford and published in Lancet Oncology in 2018.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2018\">2018<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Neurological Clinical Trials<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">A multisite clinical trial to treat the motor symptoms of Parkinson\u2019s disease began at Weill Cornell in New York.\r\n\r\nUniversity of Maryland researchers began the first US trial to open the blood-brain barrier in brain tumor patients.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2018\">2018<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">FDA Approval for Parkinson\u2019s Disease<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">On December 18, 2018, Insightec\u2019s Exablate Neuro device earned approval from the US Food and Drug Administration (FDA) to treat patients with tremor-dominant Parkinson\u2019s disease.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2019\">2019<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Clinical Trial Results Published on Opening Blood-Brain Barrier<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Clinical trial results using Carthera&#8217;s SonoCloud-1 ultrasound implant to open the blood-brain barrier (BBB) prior to chemotherapy in patients with recurrent glioblastoma were published.\r\n\r\nA clinical trial also showed it is possible to safely use MR-guided focused ultrasound to open the BBB in patients with ALS.  <\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2019\">2019<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Ultrasound Device Earns FDA Approval to Treat the Prostate<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Profound Medical\u2019s TULSA-PRO\u00ae device earned US Food and Drug Administration (FDA) approval to ablate prostate tissue. This is the first transurethral ultrasound device approved in the US, and it allows physicians to predictably ablate whole-gland or partial prostate tissue.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2020\">2020<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Reimbursement Wins<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">In February, the US Centers for Medicare and Medicaid Services (CMS) began covering focused ultrasound for tremor-dominant Parkinson\u2019s disease for many patients in the Southeast.\r\n\r\nIn July, CMS began covering focused ultrasound for essential tremor nationwide. By 2023, private payors like Aetna, Blue Cross Blue Shield, and Anthem reimbursed the procedure.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2020\">2020<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Focused Ultrasound \u201cUnicorn\u201d<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">A $150 million funding round made device manufacturer, Insightec, the first focused ultrasound unicorn (a privately held company valued over $1 billion.)<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2020\">2020<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Focused Ultrasound for Psychiatric Disorders: Clinical Trial Results Published<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Researchers at Sunnybrook Health Sciences Centre published data indicating that focused ultrasound is safe and effective in addressing the symptoms of treatment-resistant major depression and obsessive-compulsive disorder (OCD).<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2020\">2020<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">First Liver Tumor Clinical Trial Begins in the US<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">HistoSonics received approval to begin its first clinical trial in the US investigated the safety and efficacy of using the company\u2019s Edison platform to noninvasively and mechanically destroy liver tumors. The company began a similar study in Europe in early 2021.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2020\">2020<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Focused Ultrasound Approved to Treat Osteoid Osteomas<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The US FDA approved Profound Medical\u2019s Sonalleve MR-guided focused ultrasound system for the treatment of painful bone tumors \u2013 called osteoid osteomas. This was the first focused ultrasound regulatory approval to directly impact pediatric patients, and it was the sixth indication to earn approval in the US.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2021\">2021<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Regulatory Updates for Parkinson\u2019s and the Prostate<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The US FDA expanded its 2018 approval of focused ultrasound to treat tremor-dominant Parkinson\u2019s disease to include the treatment of patients with advanced Parkinson\u2019s disease suffering with mobility, rigidity, or dyskinesia symptoms.\r\n\r\nThe FDA also cleared Insightec\u2019s Exablate Prostate focused ultrasound system to ablate prostate tissue.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2021\">2021<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">World-First for Metastatic Breast Cancer<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">In a first-in-world clinical trial, researchers at Sunnybrook Health Sciences Centre in Toronto, Canada, demonstrated that MR-guided focused ultrasound can be used to safely deliver antibody therapy to breast cancer that has metastasized to the brain.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2021\">2021<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Focused Ultrasound and Liquid Biopsies<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Results of a first-in-human study found that focused ultrasound increased the amount of brain tumor biomarkers in the blood. The results suggest that focused ultrasound could reduce the need for invasive brain tumor biopsies and allow better monitoring of glioblastoma treatment responses.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2021\">2021<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Pioneering Clinical Trials<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Researchers at West Virginia University have treated the first patient in a first-in-the-world clinical trial investigating focused ultrasound to address opioid use disorder.\r\n\r\nTheraclion also received approval for its first US trial to noninvasively address varicose veins using their SONOVEIN device.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2022\">2022<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Focused Ultrasound for Veterinary Applications<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">A Foundation-funded clinical trial determined that focused ultrasound can safely ablate subcutaneous solid tumors in dogs.\r\n\r\nA team in Virginia also found that histotripsy safely and effectively treated the targeted volumes within osteosarcomas in client-owned dogs.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2022\">2022<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">Breakthroughs in Parkinson\u2019s Disease<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">Researchers in Spain used focused ultrasound to open the blood-brain barrier (BBB) in people with Parkinson\u2019s dementia.\r\n\r\nClinical trial results investigating focused ultrasound to address a possible underlying cause of Parkinson\u2019s disease were published. Researchers in Toronto tested the safety and efficacy of focused ultrasound\u2013induced BBB opening to deliver enzyme replacement therapy.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2022\">2022<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">New Brain Tumor Clinical Trials<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">In Milan, researchers will use sonodynamic therapy (SDT) in patients with newly diagnosed glioblastomas.\r\n\r\nFour sites across the US and Canada began a clinical trial to investigate focused ultrasound\u2019s role in enhancing immunotherapy for non-small cell lung cancer that has spread to the brain.\r\n\r\nResearchers in Washington, DC, began a clinical trial using SDT to address diffuse intrinsic pontine gliomas.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2023\">2023<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">University of Oxford Named a Center of Excellence<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The Focused Ultrasound Foundation has designated the University of Oxford a Center of Excellence in focused ultrasound. Oxford has become Europe\u2019s fifth Center of Excellence and eleventh worldwide.<\/p>\n                                                    <\/div>\n                                            <div class=\"swiper-slide\">\n                                                            <div class=\"relative after:absolute after:bg-brand-accent-turquoise after:h-1 after:w-full after:top-1\/2 after:px-2 after:-translate-y-1\/2 after:right-0\">\n                                    <time class=\"inline-block relative z-10 text-black bg-white text-6xl leading-none md:text-[80px] md:leading-tight\" datetime=\"2023\">2023<\/time>\n                                <\/div>\n                            \n                                \n                                <h4 class=\"font-medium text-xl leading-tight text-brand-primary-blue md:text-[2xl] md:leading-tight mt-2.5 md:mt-3.5\">US FDA Clears Focused Ultrasound for Liver Tumors<\/h4>\n                            \n                                \n                                <p class=\"text-black md:text-lg md:leading-normal mt-2 pr-5\">The US Food and Drug Administration (FDA) has cleared HistoSonics\u2019 Edison histotripsy platform to treat liver tumors. This is the ninth clinical indication for which focused ultrasound has been FDA cleared.<\/p>\n                                                    <\/div>\n                                    <\/div>\n                <div class=\"relative mt-7 md:mt-20 max-w-[1070px] mx-auto\">\n                    <div class=\"flex justify-between items-center w-full\">\n                        <button class=\"swiper-prev relative z-10 text-brand-primary-blue\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" viewBox=\"0 0 24 24\" stroke-width=\"1.5\" stroke=\"currentColor\" class=\"w-5 h-5 md:w-8 md:h-8\">\n                                <path stroke-linecap=\"round\" stroke-linejoin=\"round\" d=\"M10.5 19.5 3 12m0 0 7.5-7.5M3 12h18\" \/>\n                            <\/svg>                          \n                        <\/button>\n                        <button class=\"swiper-next relative z-10 text-brand-primary-blue\">\n                            <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" viewBox=\"0 0 24 24\" stroke-width=\"1.5\" stroke=\"currentColor\" class=\"w-5 h-5 md:w-8 md:h-8\">\n                                <path stroke-linecap=\"round\" stroke-linejoin=\"round\" d=\"M13.5 4.5 21 12m0 0-7.5 7.5M21 12H3\" \/>\n                            <\/svg>                          \n                        <\/button>\n                    <\/div>\n                    <div class=\"w-full px-6 mx-auto absolute !top-1\/2 !bottom-auto -translate-y-1\/2 md:px-11\">\n                        <div class=\"bg-brand-neutral-grayLight swiper-dots flex rounded-[10px] overflow-hidden\"><\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/section>\n\n    <script>\n        const swiper = new Swiper('.timelineSwiper', {\n            mousewheel: true,\n            slidesPerView: 1.5,\n            navigation: {\n                nextEl: \".timelineSwiper .swiper-next\",\n                prevEl: \".timelineSwiper .swiper-prev\",\n            },\n            pagination: {\n                clickable: true,\n                el: \".timelineSwiper .swiper-dots\",\n            },\n            breakpoints: {\n            768: {\n                slidesPerView: 2\n            }\n            },\n        });\n\n        const count = swiper.slides.length;\n\n        swiper.navigation.nextEl.addEventListener('click', () => {\n            swiper.slideTo(count)\n        });\n\n        swiper.navigation.prevEl.addEventListener('click', () => {\n            swiper.slideTo(0)\n        });\n    <\/script>\n\n<\/div>\n\n\n\n<p class=\"has-text-align-center\"><strong><a href=\"\/the-technology\/timeline-of-focused-ultrasound\/\" class=\"ek-link\">VIEW THE TIMELINE STARTING WITH THE MOST RECENT MILESTONES<\/a><\/strong><\/p>\n\n\n<div class=\"md:hidden\" style=\"height: 20px;\"><\/div>\n\n    <div class=\"hidden md:block\" style=\"height: 60px;\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Depending on the design of the lens and the ultrasound parameters, the target can be as small as 1\u00d71.5mm or as large as 10x16mm in diameter. Where each of the individual beams passes through the tissue, there is no effect. But, at the focal point, the convergence of the multiple beams of focused ultrasound energy &#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":435,"menu_order":34,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_searchwp_excluded":"","_editorskit_title_hidden":true,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","episode_type":"","audio_file":"","podmotor_file_id":"","podmotor_episode_id":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","filesize_raw":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","_vp_format_video_url":"","_vp_image_focal_point":[],"footnotes":""},"class_list":["post-531","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Overview - Focused Ultrasound Foundation<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fusfoundation.org\/the-technology\/overview\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Overview - Focused Ultrasound Foundation\" \/>\n<meta property=\"og:description\" content=\"Depending on the design of the lens and the ultrasound parameters, the target can be as small as 1\u00d71.5mm or as large as 10x16mm in diameter. Where each of the individual beams passes through the tissue, there is no effect. 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